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Literature summary extracted from

  • Peng, Q.; Wang, Y.; Li, M.; Yuan, D.; Xu, M.; Li, C.; Gong, Z.; Jiao, R.; Liu, L.
    cGMP-Dependent protein kinase encoded by foraging regulates motor axon guidance in Drosophila by suppressing Lola function (2016), J. Neurosci., 36, 4635-4646 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Drosophila melanogaster
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 embryo
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 Drosophila melanogaster
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2.7.11.12 ventral nerve cord
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 Drosophila melanogaster
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 additional information the enzyme PKG physically interacts with transcription factor LolaT both in vitro and in vivo Drosophila melanogaster ?
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Subunits

EC Number Subunits Comment Organism
2.7.11.12 ? x * 110000, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 FOR
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 Drosophila melanogaster
2.7.11.12 PKG
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.11.12 malfunction Drosophila embryos display targeting defects during axon development in the absence of the enzyme gene Drosophila melanogaster
2.7.11.12 physiological function the enzyme is required for CNS axon guidance. Enzyme overexpression leads to the cytoplasmic retention of transcription factor LolaT in S2 cells, suggesting a role for the enzyme in mediating the nucleocytoplasmic trafficking of Lola. The enzyme plays a role in regulating the establishment of neuronal connectivity by sequestering transcription factor Lola in the cytoplasm Drosophila melanogaster