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Literature summary extracted from

  • Singh, S.; Singh, P.K.; Suhail, H.; Arumugaswami, V.; Pellett, P.E.; Giri, S.; Kumar, A.
    Adenosine monophosphate-activated protein kinase restricts Zika virus replication in endothelial cells by potentiating innate antiviral responses and inhibiting glycolysis (2020), J. Immunol., 204, 1810-1824 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5-aminoimidazole-4-carboxamide ribonucleotide
-
 Homo sapiens
2.7.11.31 GSK621 specific isoform AMPKalpha activator Homo sapiens
2.7.11.31 metformin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.31 compound C
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.31 phosphoprotein Zika virus infection results in a decrease in AMPKalpha phosphorylation at Thr172 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 HUVEC cell
-
 Homo sapiens
-
2.7.11.31 retinal microvascular endothelial cell HRvEC cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + [acetyl-CoA carboxylase]
-
 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.31 heterotrimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 adenosine monophosphate-activated protein kinase
-
 Homo sapiens
2.7.11.31 AMP-activated kinase
-
 Homo sapiens
2.7.11.31 AMPK
-
 Homo sapiens
2.7.11.31 AMPKalpha isoform Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.11.31 malfunction enzyme ablation increases Zika virus replication and reduces innate antiviral responses Homo sapiens
2.7.11.31 physiological function the enzyme has an antiviral effect on Zika virus replication. The anti-Zika virus effect of enzyme signaling in endothelial cells is mediated by reduction of viral-induced glycolysis and enhanced innate antiviral responses Homo sapiens