EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.12 | Drosophila melanogaster | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.12 | neuron | - |
Drosophila melanogaster | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.12 | FOR | - |
Drosophila melanogaster |
2.7.11.12 | PKG | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.11.12 | physiological function | the presynaptic, but not postsynaptic or glial, enzyme gene is required for synaptic vesicle recycling. The enzyme gene FOR inhibits synaptic vesicle exocytosis during low-frequency stimulation by negatively regulating presynaptic Ca2+ levels and maintains neurotransmission during high-frequency stimulation by facilitating synaptic vesicle endocytosis. Additionally, glial FOR gene negatively regulated nerve terminal growth through TGF-beta signalling, and this developmental effect is independent of the effects of the enzyme gene on neurotransmission. Overall, the enzyme gene plays a critical role in coupling synaptic vesicle exocytosis and endocytosis, thereby balancing these two components to maintain sustained neurotransmission | Drosophila melanogaster |