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Literature summary extracted from

  • Singh, A.; Das, M.; Grover, A.
    Molecular mechanism of acetoacetyl-CoA enhanced kinetics for increased bioplastic production from Cupriavidus necator 428 (2020), J. Biomol. Struct. Dyn., 38, 827-840 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.36 Q47L the mutant shows with increased enzymatic efficiency compared to the wild type enzyme Cupriavidus necator
1.1.1.36 T173S the mutant shows with increased enzymatic efficiency compared to the wild type enzyme Cupriavidus necator

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.36 acetoacetyl-CoA + NADPH + H+ Cupriavidus necator
-
 (R)-3-hydroxybutyryl-CoA + NADP+
-
 r
1.1.1.36 acetoacetyl-CoA + NADPH + H+ Cupriavidus necator DSM 428
-
 (R)-3-hydroxybutyryl-CoA + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.36 Cupriavidus necator P14697
-
-
1.1.1.36 Cupriavidus necator DSM 428 P14697
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.36 acetoacetyl-CoA + NADPH + H+
-
 Cupriavidus necator (R)-3-hydroxybutyryl-CoA + NADP+
-
 r
1.1.1.36 acetoacetyl-CoA + NADPH + H+
-
 Cupriavidus necator DSM 428 (R)-3-hydroxybutyryl-CoA + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.36 NADPH-dependent acetoacetyl-coenzyme A reductase
-
 Cupriavidus necator
1.1.1.36 PhaB
-
 Cupriavidus necator

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.36 NADPH
-
 Cupriavidus necator