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Literature summary extracted from

  • Konarzewska, P.; Wang, Y.; Han, G.S.; Goh, K.J.; Gao, Y.G.; Carman, G.M.; Xue, C.
    Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans (2019), J. Biol. Chem., 294, 2329-2339 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.8 endoplasmic reticulum
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 Cryptococcus neoformans 5783
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Organism

EC Number Organism UniProt Comment Textmining
2.7.8.8 Cryptococcus neoformans
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.8.8 CHO1
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 Cryptococcus neoformans

General Information

EC Number General Information Comment Organism
2.7.8.8 physiological function expression of Cho1 in a Saccharomyces cerevisiae Cho1 deletion mutant rescues the mutant's growth defect in the absence of ethanolamine supplementation. An Saccharomyces cerevisiae Cho1 deletion mutant expressing Cryptococcus neoformans Cho1 has phosphatidylserine synthase activity. Expression of Cho1 in Cryptococcus neoformans is essential for mitochondrial function and cell viability. Its deficiency cannot be complemented by ethanolamine or choline supplementation Cryptococcus neoformans