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Literature summary extracted from
- The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates (2019), J. Biol. Chem., 294, 14768-14775 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.205 | Ap4A | slight activation | Eremothecium gossypii |  |
| 1.1.1.205 | Ap5A | slight activation | Eremothecium gossypii | |
| 1.1.1.205 | Ap6A | slight activation | Eremothecium gossypii | |
| 1.1.1.205 | ATP | slight activation | Eremothecium gossypii | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.205 | expressed in Escherichia coli BL21 cells | Eremothecium gossypii |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.1.1.205 | enzyme in complex with Ap5G and GDP, vapor diffusion method, using 20% (w/v) PEG-6000, 0.1 M sodium acetate, pH 5.0, 0.2 M sodium chloride | Eremothecium gossypii |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.205 | GDP | - |
Eremothecium gossypii | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.205 | Mg2+ | 1 mM used in assay conditions | Eremothecium gossypii | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.205 | IMP + NAD+ + H2O | Eremothecium gossypii | - |
XMP + NADH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.205 | Eremothecium gossypii | Q756Z6 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.205 | HisTrap column chromatography and Sephacryl S-300 gel filtration | Eremothecium gossypii |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.205 | IMP + NAD+ + H2O | - |
Eremothecium gossypii | XMP + NADH + H+ | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.205 | tetramer | small angle X-ray scattering | Eremothecium gossypii |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.205 | IMPDH | - |
Eremothecium gossypii |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.205 | NAD+ | - |
Eremothecium gossypii | |
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Release 2023.1 (January 2023)
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