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Literature summary extracted from

  • Zhong, R.; Liang, B.; Xin, R.; Zhu, X.; Liu, Z.; Chen, Q.; Hou, Y.; Jin, Z.; Qi, M.; Ma, S.; Liu, X.
    Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells (2018), Int. J. Oncol., 52, 1000-1010 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 additional information the enzyme is activated in response to ionizing radiation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.74 S74A the mutation abrogates phosphorylation of the protein Homo sapiens
2.7.1.74 S74E the mutation mimics phosphorylation of the protein Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 NTP + deoxycytidine Homo sapiens
-
 NDP + dCMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens P27707
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.74 phosphoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 breast cancer cell
-
 Homo sapiens
-
2.7.1.74 MDA-MB-231 cell
-
 Homo sapiens
-
2.7.1.74 SK-BR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.74 physiological function the phosphorylated and activated enzyme inhibits IR-induced total cell death and apoptosis, and promotes ionizing radiation-induced autophagy through the phospho-mammalian target of rapamycin pathway and by inhibiting the binding of Bcl-2 protein to Bcl-2/Beclin1 Homo sapiens