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Literature summary extracted from

  • Ansari, M.; Ahsan, M.; Yasmin, S.; Sahoo, G.; Saini, V.; Das, P.
    In silico identification of novel antagonists and binding insights by structural and functional analyses of guanylate kinase of Leishmania donovani and interaction with inhibitors (2017), Gene Rep., 8, 134-143 .
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.8 diospyrin
-
 Leishmania donovani
2.7.4.8 additional information in silico identification of novel antagonists and binding insights by structural and functional analyses of guanylate kinase of Leishmania donovani and interaction with inhibitors Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.8 ATP + GMP Leishmania donovani
-
 ADP + GDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.8 Leishmania donovani
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.8 ATP + GMP
-
 Leishmania donovani ADP + GDP
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.4.8 0.0072
-
 pH and temperature not specified in the publication Leishmania donovani diospyrin

General Information

EC Number General Information Comment Organism
2.7.4.8 drug target success for treatment with 5'-guanylic acid in conjunction first-line antileishmanial therapies Leishmania donovani