EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.8.5 | Bacillus subtilis | P46322 | - |
- |
2.7.8.5 | Bacillus subtilis 168 | P46322 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.8.5 | pgsA | - |
Bacillus subtilis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.8.5 | physiological function | the genes encoding cell shape determination protein Rodz and PgsA are co-transcribed and both a RodZ mutant and a conditional PgsA mutant, under conditions of minimal PgsA expression, are sensitive to sorbic and acetic acid. Both strains display a severely altered membrane composition. Compared to the wild-type strain, phosphatidylglycerol and cardiolipin levels are lowered and the average acyl chain length is elongated. Induction of RodZ expression from a plasmid in the mutant leads to no recovery of weak acid susceptibility comparable to wild-type levels. PgsA overexpression in the same mutant partly restores sorbic acid susceptibility and fully restores acetic acid sensitivity. A construct containing both RodZ and PgsA as on the genome leads to some restored growth as well | Bacillus subtilis |