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Literature summary extracted from

  • Blunsom, N.J.; Cockcroft, S.
    CDP-diacylglycerol synthases (CDS) gateway to phosphatidylinositol and cardiolipin synthesis (2020), Front. Cell Dev. Biol., 8, 63 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.41 apicoplast
-
 Toxoplasma gondii 20011
-
2.7.7.41 apicoplast
-
 Eimeria falciformis 20011
-
2.7.7.41 endoplasmic reticulum
-
 Drosophila melanogaster 5783
-
2.7.7.41 endoplasmic reticulum
-
 Saccharomyces cerevisiae 5783
-
2.7.7.41 endoplasmic reticulum
-
 Schizosaccharomyces pombe 5783
-
2.7.7.41 endoplasmic reticulum
-
 Trypanosoma brucei brucei 5783
-
2.7.7.41 endoplasmic reticulum
-
 Toxoplasma gondii 5783
-
2.7.7.41 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.7.7.41 endoplasmic reticulum
-
 Arabidopsis thaliana 5783
-
2.7.7.41 endoplasmic reticulum
-
 Eimeria falciformis 5783
-
2.7.7.41 Golgi apparatus
-
 Trypanosoma brucei brucei 5794
-
2.7.7.41 membrane integral membrane protein Drosophila melanogaster 16020
-
2.7.7.41 membrane integral membrane protein Saccharomyces cerevisiae 16020
-
2.7.7.41 membrane integral membrane protein Schizosaccharomyces pombe 16020
-
2.7.7.41 membrane integral membrane protein Thermotoga maritima 16020
-
2.7.7.41 membrane integral membrane protein Streptococcus mitis 16020
-
2.7.7.41 membrane integral membrane protein Streptococcus oralis 16020
-
2.7.7.41 membrane integral membrane protein Trypanosoma brucei brucei 16020
-
2.7.7.41 membrane integral membrane protein Aeropyrum pernix 16020
-
2.7.7.41 membrane integral membrane protein Toxoplasma gondii 16020
-
2.7.7.41 membrane integral membrane protein Homo sapiens 16020
-
2.7.7.41 membrane integral membrane protein Arabidopsis thaliana 16020
-
2.7.7.41 membrane integral membrane protein Escherichia coli 16020
-
2.7.7.41 membrane integral membrane protein Eimeria falciformis 16020
-
2.7.7.41 mitochondrion
-
 Danio rerio 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.41 additional information divalent cations are essential for activity Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.41 CTP + phosphatidate Drosophila melanogaster
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Saccharomyces cerevisiae
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Schizosaccharomyces pombe
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Thermotoga maritima
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Streptococcus mitis
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Streptococcus oralis
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Trypanosoma brucei brucei
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Aeropyrum pernix
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Toxoplasma gondii
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Homo sapiens
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Arabidopsis thaliana
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Danio rerio
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Escherichia coli
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Eimeria falciformis
-
 diphosphate + CDP-diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.41 Aeropyrum pernix
-
-
-
2.7.7.41 Arabidopsis thaliana O04928
-
-
2.7.7.41 Arabidopsis thaliana O49639
-
-
2.7.7.41 Arabidopsis thaliana Q1PE48
-
-
2.7.7.41 Arabidopsis thaliana Q94A03
-
-
2.7.7.41 Arabidopsis thaliana Q9M001
-
-
2.7.7.41 Danio rerio Q3B7H2
-
-
2.7.7.41 Drosophila melanogaster
-
-
-
2.7.7.41 Eimeria falciformis
-
-
-
2.7.7.41 Escherichia coli P0ABG1
-
-
2.7.7.41 Homo sapiens Q92903
-
-
2.7.7.41 Homo sapiens Q95674
-
-
2.7.7.41 Saccharomyces cerevisiae
-
-
-
2.7.7.41 Schizosaccharomyces pombe
-
-
-
2.7.7.41 Streptococcus mitis
-
-
-
2.7.7.41 Streptococcus oralis
-
-
-
2.7.7.41 Thermotoga maritima
-
-
-
2.7.7.41 Toxoplasma gondii
-
-
-
2.7.7.41 Trypanosoma brucei brucei
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.41 eye
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.41 CTP + phosphatidate
-
 Drosophila melanogaster diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Saccharomyces cerevisiae diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Schizosaccharomyces pombe diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Thermotoga maritima diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Streptococcus mitis diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Streptococcus oralis diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Trypanosoma brucei brucei diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Aeropyrum pernix diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Toxoplasma gondii diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Homo sapiens diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Arabidopsis thaliana diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Danio rerio diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Escherichia coli diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Eimeria falciformis diphosphate + CDP-diacylglycerol
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.41 ? x * 27000, SDS-PAGE Escherichia coli
2.7.7.41 homodimer 2 * 52000, SDS-PAGE Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.7.7.41 CarS
-
 Aeropyrum pernix
2.7.7.41 CDP-DAG synthase
-
 Drosophila melanogaster
2.7.7.41 CDP-DAG synthase
-
 Saccharomyces cerevisiae
2.7.7.41 CDP-DAG synthase
-
 Schizosaccharomyces pombe
2.7.7.41 CDP-DAG synthase
-
 Thermotoga maritima
2.7.7.41 CDP-DAG synthase
-
 Streptococcus mitis
2.7.7.41 CDP-DAG synthase
-
 Streptococcus oralis
2.7.7.41 CDP-DAG synthase
-
 Trypanosoma brucei brucei
2.7.7.41 CDP-DAG synthase
-
 Aeropyrum pernix
2.7.7.41 CDP-DAG synthase
-
 Toxoplasma gondii
2.7.7.41 CDP-DAG synthase
-
 Homo sapiens
2.7.7.41 CDP-DAG synthase
-
 Arabidopsis thaliana
2.7.7.41 CDP-DAG synthase
-
 Danio rerio
2.7.7.41 CDP-DAG synthase
-
 Escherichia coli
2.7.7.41 CDP-DAG synthase
-
 Eimeria falciformis
2.7.7.41 CDP-diacylglycerol synthase
-
 Drosophila melanogaster
2.7.7.41 CDP-diacylglycerol synthase
-
 Saccharomyces cerevisiae
2.7.7.41 CDP-diacylglycerol synthase
-
 Schizosaccharomyces pombe
2.7.7.41 CDP-diacylglycerol synthase
-
 Thermotoga maritima
2.7.7.41 CDP-diacylglycerol synthase
-
 Streptococcus mitis
2.7.7.41 CDP-diacylglycerol synthase
-
 Streptococcus oralis
2.7.7.41 CDP-diacylglycerol synthase
-
 Trypanosoma brucei brucei
2.7.7.41 CDP-diacylglycerol synthase
-
 Aeropyrum pernix
2.7.7.41 CDP-diacylglycerol synthase
-
 Toxoplasma gondii
2.7.7.41 CDP-diacylglycerol synthase
-
 Homo sapiens
2.7.7.41 CDP-diacylglycerol synthase
-
 Arabidopsis thaliana
2.7.7.41 CDP-diacylglycerol synthase
-
 Danio rerio
2.7.7.41 CDP-diacylglycerol synthase
-
 Escherichia coli
2.7.7.41 CDP-diacylglycerol synthase
-
 Eimeria falciformis
2.7.7.41 CDS
-
 Drosophila melanogaster
2.7.7.41 CDS
-
 Saccharomyces cerevisiae
2.7.7.41 CDS
-
 Schizosaccharomyces pombe
2.7.7.41 CDS
-
 Thermotoga maritima
2.7.7.41 CDS
-
 Streptococcus mitis
2.7.7.41 CDS
-
 Streptococcus oralis
2.7.7.41 CDS
-
 Trypanosoma brucei brucei
2.7.7.41 CDS
-
 Aeropyrum pernix
2.7.7.41 CDS
-
 Arabidopsis thaliana
2.7.7.41 CDS
-
 Danio rerio
2.7.7.41 CDS
-
 Escherichia coli
2.7.7.41 CDS
-
 Eimeria falciformis
2.7.7.41 CDS1 isoform Toxoplasma gondii
2.7.7.41 CDS1 isoform Homo sapiens
2.7.7.41 CDS1 isoform Arabidopsis thaliana
2.7.7.41 CDS1 isoform Eimeria falciformis
2.7.7.41 CDS2 isoform Toxoplasma gondii
2.7.7.41 CDS2 isoform Arabidopsis thaliana
2.7.7.41 CDS2 isoform Homo sapiens
2.7.7.41 CDS2 isoform Eimeria falciformis
2.7.7.41 CDS3 isoform Arabidopsis thaliana
2.7.7.41 Cds4 isoform Arabidopsis thaliana
2.7.7.41 Cds5 isoform Arabidopsis thaliana
2.7.7.41 CdsA
-
 Drosophila melanogaster
2.7.7.41 CdsA
-
 Saccharomyces cerevisiae
2.7.7.41 CdsA
-
 Thermotoga maritima
2.7.7.41 CdsA
-
 Streptococcus mitis
2.7.7.41 CdsA
-
 Streptococcus oralis
2.7.7.41 CdsA
-
 Escherichia coli
2.7.7.41 Tam41
-
 Schizosaccharomyces pombe
2.7.7.41 TAMM41
-
 Danio rerio
2.7.7.41 YnbD
-
 Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.41 7.5
-
-
 Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
2.7.7.41 malfunction enzyme knockout causes abnormal heart development, specifically a defect in heart valve formation Danio rerio
2.7.7.41 malfunction enzyme mutations cause resistance to daptomycin Streptococcus mitis
2.7.7.41 malfunction enzyme mutations cause resistance to daptomycin Streptococcus oralis
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Drosophila melanogaster
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Saccharomyces cerevisiae
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Schizosaccharomyces pombe
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Thermotoga maritima
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Streptococcus mitis
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Streptococcus oralis
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Trypanosoma brucei brucei
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Aeropyrum pernix
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Toxoplasma gondii
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Homo sapiens
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Arabidopsis thaliana
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Danio rerio
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Escherichia coli
2.7.7.41 metabolism the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling Eimeria falciformis
2.7.7.41 physiological function the enzyme is essential for embryogenesis, phototransduction, metamorphosis, and spermatogenesis Drosophila melanogaster
2.7.7.41 physiological function the enzyme participates in regulating heart valve formation through mediating PINK1-dependent mitophagy Danio rerio