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Literature summary extracted from

  • Yip, C.K.Y.; Bansal, S.; Wong, S.Y.; Lau, A.J.
    Identification of galeterone and abiraterone as inhibitors of dehydroepiandrosterone sulfonation catalyzed by human hepatic cytosol, SULT2A1, SULT2B1b, and SULT1E1 (2018), Drug Metab. Dispos., 46, 470-482 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.2 abiraterone antiandrogen drug, metabolite abiraterone, not the parent drug abiraterone acetate, is responsible for the inhibition; antiandrogen drug, metabolite abiraterone, not the parent drug abiraterone acetate, is responsible for the inhibition Homo sapiens
2.8.2.2 cyproterone acetate
-
 Homo sapiens
2.8.2.2 danazol
-
 Homo sapiens
2.8.2.2 galeterone antiandrogen drug; antiandrogen drug Homo sapiens
2.8.2.2 spironolactone
-
 Homo sapiens
2.8.2.4 abiraterone antiandrogen drug, metabolite abiraterone, not the parent drug abiraterone acetate, is responsible for the inhibition Homo sapiens
2.8.2.4 cyproterone acetate
-
 Homo sapiens
2.8.2.4 danazol
-
 Homo sapiens
2.8.2.4 galeterone antiandrogen drug Homo sapiens
2.8.2.4 spironolactone
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.2 cytosol
-
 Homo sapiens 5829
-
2.8.2.4 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Homo sapiens O00204 isoform SULT2B1
-
2.8.2.2 Homo sapiens Q06520 isoform SULT2A1
-
2.8.2.4 Homo sapiens P49888 isoform SULT1E1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 intestine
-
 Homo sapiens
-
2.8.2.2 liver
-
 Homo sapiens
-
2.8.2.4 intestine
-
 Homo sapiens
-
2.8.2.4 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 SULT2A1
-
 Homo sapiens
2.8.2.2 SULT2B1
-
 Homo sapiens
2.8.2.4 SULT1E1
-
 Homo sapiens