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Literature summary extracted from

  • Ramsden, D.; Smith, D.; Arenas, R.; Frederick, K.; Cerny, M.A.
    Identification and characterization of a selective human carbonyl reductase 1 substrate (2018), Drug Metab. Dispos., 46, 1434-1440 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 Disulfiram 43.5% inhibition at 0.1 mM Homo sapiens
1.1.1.184 Ethacrynic acid 34.4% inhibition at 0.1 mM Homo sapiens
1.1.1.184 menadione 32.6% inhibition at 0.01 mM, 95.7% inhibition at 0.1 mM Homo sapiens
1.1.1.184 quercetin 56.4% inhibition at 0.01 mM, 81.6% inhibition at 0.1 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.184 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Homo sapiens P16152
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 6-(4-acetyl-5-fluoropyridin-3-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide + NADPH + H+ selective substrate of human carbonyl reductase 1 Homo sapiens 6-[5-fluoro-4-[(1R)-1-hydroxyethyl]pyridin-3-yl]-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.184 carbonyl reductase 1
-
 Homo sapiens
1.1.1.184 CBR1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.184 NADPH
-
 Homo sapiens