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Literature summary extracted from

  • Burbank, M.G.; Burban, A.; Sharanek, A.; Weaver, R.J.; Guguen-Guillouzo, C.; Guillouzo, A.
    Early alterations of bile canaliculi dynamics and the Rho kinase/myosin light chain kinase pathway are characteristics of drug-induced intrahepatic cholestasis (2016), Drug Metab. Dispos., 44, 1780-1793 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 Calmodulin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 bosentan
-
 Homo sapiens
2.7.11.18 cimetidine
-
 Homo sapiens
2.7.11.18 diclofenac
-
 Homo sapiens
2.7.11.18 entacapone
-
 Homo sapiens
2.7.11.18 tacrolimus
-
 Homo sapiens
2.7.11.18 tolcapone
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + [myosin light chain] Homo sapiens
-
 ADP + [myosin light chain] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 Hepa-RG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + [myosin light chain]
-
 Homo sapiens ADP + [myosin light chain] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Homo sapiens