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Literature summary extracted from

  • Li, H.; Rai, M.; Buddika, K.; Sterrett, M.; Luhur, A.; Mahmoudzadeh, N.; Julick, C.; Pletcher, R.; Chawla, G.; Gosney, C.; Burton, A.; Karty, J.; Montooth, K.; Sokol, N.; Tennessen, J.
    Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development (2019), Development, 146, dev175315 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.8 Drosophila melanogaster P13706
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.8 larva
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 Drosophila melanogaster
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Synonyms

EC Number Synonyms Comment Organism
1.1.1.8 GPDH1
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
1.1.1.8 physiological function GPDH1 regulates larval NAD+/NADH redox balance and ATP levels. Larvae lacking both lactate dehydrogenase and G3P dehydrogenase (GPDH1) exhibit growth defects, synthetic lethality and decreased glycolytic flux, simultaneous loss of LDH and GPDH1 disrupts ATP homeostasis and glycolytic flux Drosophila melanogaster