Literature summary extracted from

Pham, T.H.; Liang, Z.X.; Marcellin, E.; Turner, M.S.
Replenishing the cyclic-di-AMP pool regulation of diadenylate cyclase activity in bacteria (2016), Curr. Genet., 62, 731-738 .

Activating Compound

EC Number	Activating Compound	Comment	Organism
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus subtilis
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Staphylococcus aureus
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus pneumoniae
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus mutans serotype c
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus pyogenes serotype M2
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus equi subsp. zooepidemicus
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Enterococcus faecalis
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus amyloliquefaciens
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus licheniformis
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus anthracis
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Tetragenococcus halophilus
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium novyi
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium ljungdahlii
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium perfringens
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium botulinum
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Geobacter sulfurreducens
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Listeria monocytogenes EGD
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Lactococcus cremoris
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Lacticaseibacillus rhamnosus
2.7.7.85	CdaR	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Lactobacillus acidophilus

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Bacillus subtilis
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Staphylococcus aureus
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Streptococcus pneumoniae
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Streptococcus mutans serotype c
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Streptococcus pyogenes serotype M2
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Streptococcus equi subsp. zooepidemicus
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Enterococcus faecalis
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Bacillus amyloliquefaciens
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Bacillus licheniformis
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Bacillus anthracis
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Tetragenococcus halophilus
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Clostridium novyi
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Clostridium ljungdahlii
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Clostridium perfringens
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Clostridium botulinum
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Geobacter sulfurreducens
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Listeria monocytogenes EGD
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Lactococcus cremoris
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Lacticaseibacillus rhamnosus
2.7.7.85	gene cdaA, genetic organization of CdaA, CdaR, and GlmM encoding genes	Lactobacillus acidophilus

Inhibitors

EC Number	Inhibitors	Comment	Organism
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Bacillus amyloliquefaciens
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Bacillus anthracis
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Bacillus licheniformis
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Bacillus subtilis
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Clostridium botulinum
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Clostridium ljungdahlii
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Clostridium novyi
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Clostridium perfringens
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Enterococcus faecalis
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Geobacter sulfurreducens
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Lacticaseibacillus rhamnosus
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Lactobacillus acidophilus
2.7.7.85	3'-deoxyATP	cordycepin triphosphate; cordycepin triphosphate	Lactococcus cremoris
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Listeria monocytogenes EGD
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Staphylococcus aureus
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Streptococcus equi subsp. zooepidemicus
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Streptococcus mutans serotype c
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Streptococcus pneumoniae
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Streptococcus pyogenes serotype M2
2.7.7.85	3'-deoxyATP	cordycepin triphosphate	Tetragenococcus halophilus
2.7.7.85	cordycepin	3'-deoxy adenosine	Bacillus amyloliquefaciens
2.7.7.85	cordycepin	3'-deoxy adenosine	Bacillus anthracis
2.7.7.85	cordycepin	3'-deoxy adenosine	Bacillus licheniformis
2.7.7.85	cordycepin	3'-deoxy adenosine	Bacillus subtilis
2.7.7.85	cordycepin	3'-deoxy adenosine	Clostridium botulinum
2.7.7.85	cordycepin	3'-deoxy adenosine	Clostridium ljungdahlii
2.7.7.85	cordycepin	3'-deoxy adenosine	Clostridium novyi
2.7.7.85	cordycepin	3'-deoxy adenosine	Clostridium perfringens
2.7.7.85	cordycepin	3'-deoxy adenosine	Enterococcus faecalis
2.7.7.85	cordycepin	3'-deoxy adenosine	Geobacter sulfurreducens
2.7.7.85	cordycepin	3'-deoxy adenosine	Lacticaseibacillus rhamnosus
2.7.7.85	cordycepin	3'-deoxy adenosine	Lactobacillus acidophilus
2.7.7.85	cordycepin	3'-deoxy adenosine; 3'-deoxy adenosine	Lactococcus cremoris
2.7.7.85	cordycepin	3'-deoxy adenosine	Listeria monocytogenes EGD
2.7.7.85	cordycepin	3'-deoxy adenosine	Staphylococcus aureus
2.7.7.85	cordycepin	3'-deoxy adenosine	Streptococcus equi subsp. zooepidemicus
2.7.7.85	cordycepin	3'-deoxy adenosine	Streptococcus mutans serotype c
2.7.7.85	cordycepin	3'-deoxy adenosine	Streptococcus pneumoniae
2.7.7.85	cordycepin	3'-deoxy adenosine	Streptococcus pyogenes serotype M2
2.7.7.85	cordycepin	3'-deoxy adenosine	Tetragenococcus halophilus
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus amyloliquefaciens
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus anthracis
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus licheniformis
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Bacillus subtilis
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium botulinum
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium ljungdahlii
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium novyi
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Clostridium perfringens
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Enterococcus faecalis
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Geobacter sulfurreducens
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Lacticaseibacillus rhamnosus
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Lactobacillus acidophilus
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex; binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Lactococcus cremoris
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Listeria monocytogenes EGD
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Staphylococcus aureus
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus equi subsp. zooepidemicus
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus mutans serotype c
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus pneumoniae
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Streptococcus pyogenes serotype M2
2.7.7.85	GlmM	binds directly to enzyme CdaA in the CdaA-CdaR-GlmM protein complex	Tetragenococcus halophilus
2.7.7.85	suramin	-	Bacillus amyloliquefaciens
2.7.7.85	suramin	-	Bacillus anthracis
2.7.7.85	suramin	-	Bacillus licheniformis
2.7.7.85	suramin	-	Bacillus subtilis
2.7.7.85	suramin	-	Clostridium botulinum
2.7.7.85	suramin	-	Clostridium ljungdahlii
2.7.7.85	suramin	-	Clostridium novyi
2.7.7.85	suramin	-	Clostridium perfringens
2.7.7.85	suramin	-	Enterococcus faecalis
2.7.7.85	suramin	-	Geobacter sulfurreducens
2.7.7.85	suramin	-	Lacticaseibacillus rhamnosus
2.7.7.85	suramin	-	Lactobacillus acidophilus
2.7.7.85	suramin	-	Lactococcus cremoris
2.7.7.85	suramin	-	Listeria monocytogenes EGD
2.7.7.85	suramin	-	Staphylococcus aureus
2.7.7.85	suramin	-	Streptococcus equi subsp. zooepidemicus
2.7.7.85	suramin	-	Streptococcus mutans serotype c
2.7.7.85	suramin	-	Streptococcus pneumoniae
2.7.7.85	suramin	-	Streptococcus pyogenes serotype M2
2.7.7.85	suramin	-	Tetragenococcus halophilus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.7.7.85	membrane	-	Bacillus subtilis	16020	-
2.7.7.85	membrane	-	Staphylococcus aureus	16020	-
2.7.7.85	membrane	-	Streptococcus pneumoniae	16020	-
2.7.7.85	membrane	-	Streptococcus mutans serotype c	16020	-
2.7.7.85	membrane	-	Streptococcus pyogenes serotype M2	16020	-
2.7.7.85	membrane	-	Streptococcus equi subsp. zooepidemicus	16020	-
2.7.7.85	membrane	-	Enterococcus faecalis	16020	-
2.7.7.85	membrane	-	Bacillus amyloliquefaciens	16020	-
2.7.7.85	membrane	-	Bacillus licheniformis	16020	-
2.7.7.85	membrane	-	Bacillus anthracis	16020	-
2.7.7.85	membrane	-	Tetragenococcus halophilus	16020	-
2.7.7.85	membrane	-	Clostridium novyi	16020	-
2.7.7.85	membrane	-	Clostridium ljungdahlii	16020	-
2.7.7.85	membrane	-	Clostridium perfringens	16020	-
2.7.7.85	membrane	-	Clostridium botulinum	16020	-
2.7.7.85	membrane	-	Geobacter sulfurreducens	16020	-
2.7.7.85	membrane	-	Listeria monocytogenes EGD	16020	-
2.7.7.85	membrane	-	Lactococcus cremoris	16020	-
2.7.7.85	membrane	-	Lacticaseibacillus rhamnosus	16020	-
2.7.7.85	membrane	-	Lactobacillus acidophilus	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
2.7.7.85	2 ATP	Bacillus subtilis	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Staphylococcus aureus	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus pneumoniae	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus mutans serotype c	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus pyogenes serotype M2	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus equi subsp. zooepidemicus	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Enterococcus faecalis	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus amyloliquefaciens	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus anthracis	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Tetragenococcus halophilus	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium novyi	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium ljungdahlii	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium perfringens	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium botulinum	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Geobacter sulfurreducens	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Listeria monocytogenes EGD	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactococcus cremoris	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lacticaseibacillus rhamnosus	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactobacillus acidophilus	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Tetragenococcus halophilus JCM 20259	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Listeria monocytogenes EGD EGD-e	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactococcus cremoris Sk11	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Staphylococcus aureus NCTC 8325	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus subtilis 168	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Tetragenococcus halophilus DSM 20338	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Tetragenococcus halophilus NCIMB 9735	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium ljungdahlii DSM 13528	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis NCIMB 9375	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Enterococcus faecalis ERV62	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis Gibson 46	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium novyi NT	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium perfringens NCIMB 6125	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium perfringens NCTC 8237	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium perfringens JCM 1290	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis JCM 2505	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus mutans serotype c ATCC 700610	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Tetragenococcus halophilus NBRC 12172	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactococcus cremoris MG1363	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactobacillus acidophilus NCFM	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus pyogenes serotype M2 MGAS10270	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis NRRL NRS-1264	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium perfringens type A	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lacticaseibacillus rhamnosus ATCC 8530	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Geobacter sulfurreducens PCA	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium ljungdahlii PETC	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus pneumoniae ATCC 700669	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Listeria monocytogenes EGD ATCC BAA-679	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactobacillus acidophilus ATCC 700396	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Geobacter sulfurreducens ATCC 51573	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactobacillus acidophilus NCK56	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium perfringens DSM 756	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis NBRC 12200	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Staphylococcus aureus PS 47	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis ATCC 14580	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Lactobacillus acidophilus N2	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Streptococcus mutans serotype c UA159	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Bacillus licheniformis DSM 13	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Clostridium ljungdahlii ATCC 55383	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	Geobacter sulfurreducens DSM 12127	-	2 diphosphate + cyclic di-3',5'-adenylate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.85	Bacillus amyloliquefaciens	A0A0D7XMK3	-	-
2.7.7.85	Bacillus anthracis	A0A2A8KZ47	-	-
2.7.7.85	Bacillus licheniformis	Q65P49	-	-
2.7.7.85	Bacillus licheniformis ATCC 14580	Q65P49	-	-
2.7.7.85	Bacillus licheniformis DSM 13	Q65P49	-	-
2.7.7.85	Bacillus licheniformis Gibson 46	Q65P49	-	-
2.7.7.85	Bacillus licheniformis JCM 2505	Q65P49	-	-
2.7.7.85	Bacillus licheniformis NBRC 12200	Q65P49	-	-
2.7.7.85	Bacillus licheniformis NCIMB 9375	Q65P49	-	-
2.7.7.85	Bacillus licheniformis NRRL NRS-1264	Q65P49	-	-
2.7.7.85	Bacillus subtilis	Q45589	-	-
2.7.7.85	Bacillus subtilis 168	Q45589	-	-
2.7.7.85	Clostridium botulinum	A0A0C2N691	-	-
2.7.7.85	Clostridium ljungdahlii	D8GIJ7	-	-
2.7.7.85	Clostridium ljungdahlii ATCC 55383	D8GIJ7	-	-
2.7.7.85	Clostridium ljungdahlii DSM 13528	D8GIJ7	-	-
2.7.7.85	Clostridium ljungdahlii PETC	D8GIJ7	-	-
2.7.7.85	Clostridium novyi	A0PXZ3	-	-
2.7.7.85	Clostridium novyi NT	A0PXZ3	-	-
2.7.7.85	Clostridium perfringens	A0A0H2YU52	-	-
2.7.7.85	Clostridium perfringens DSM 756	A0A0H2YU52	-	-
2.7.7.85	Clostridium perfringens JCM 1290	A0A0H2YU52	-	-
2.7.7.85	Clostridium perfringens NCIMB 6125	A0A0H2YU52	-	-
2.7.7.85	Clostridium perfringens NCTC 8237	A0A0H2YU52	-	-
2.7.7.85	Clostridium perfringens type A	A0A0H2YU52	-	-
2.7.7.85	Enterococcus faecalis	A0A2Z6BU13	-	-
2.7.7.85	Enterococcus faecalis ERV62	A0A2Z6BU13	-	-
2.7.7.85	Geobacter sulfurreducens	Q74EU1	-	-
2.7.7.85	Geobacter sulfurreducens ATCC 51573	Q74EU1	-	-
2.7.7.85	Geobacter sulfurreducens DSM 12127	Q74EU1	-	-
2.7.7.85	Geobacter sulfurreducens PCA	Q74EU1	-	-
2.7.7.85	Lacticaseibacillus rhamnosus	A0A2A5L6R6	-	-
2.7.7.85	Lacticaseibacillus rhamnosus ATCC 8530	A0A2A5L6R6	-	-
2.7.7.85	Lactobacillus acidophilus	Q5FL37	-	-
2.7.7.85	Lactobacillus acidophilus ATCC 700396	Q5FL37	-	-
2.7.7.85	Lactobacillus acidophilus N2	Q5FL37	-	-
2.7.7.85	Lactobacillus acidophilus NCFM	Q5FL37	-	-
2.7.7.85	Lactobacillus acidophilus NCK56	Q5FL37	-	-
2.7.7.85	Lactococcus cremoris	A2RIF7	-	-
2.7.7.85	Lactococcus cremoris	Q031P4	-	-
2.7.7.85	Lactococcus cremoris MG1363	A2RIF7	-	-
2.7.7.85	Lactococcus cremoris Sk11	Q031P4	-	-
2.7.7.85	Listeria monocytogenes EGD	Q8Y5E4	-	-
2.7.7.85	Listeria monocytogenes EGD ATCC BAA-679	Q8Y5E4	-	-
2.7.7.85	Listeria monocytogenes EGD EGD-e	Q8Y5E4	-	-
2.7.7.85	Staphylococcus aureus	Q2FW92	-	-
2.7.7.85	Staphylococcus aureus NCTC 8325	Q2FW92	-	-
2.7.7.85	Staphylococcus aureus PS 47	Q2FW92	-	-
2.7.7.85	Streptococcus equi subsp. zooepidemicus	A0A2X3T317	-	-
2.7.7.85	Streptococcus mutans serotype c	Q8DTC4	-	-
2.7.7.85	Streptococcus mutans serotype c ATCC 700610	Q8DTC4	-	-
2.7.7.85	Streptococcus mutans serotype c UA159	Q8DTC4	-	-
2.7.7.85	Streptococcus pneumoniae	A0A0B7L730	-	-
2.7.7.85	Streptococcus pneumoniae ATCC 700669	A0A0B7L730	-	-
2.7.7.85	Streptococcus pyogenes serotype M2	Q1JH51	-	-
2.7.7.85	Streptococcus pyogenes serotype M2 MGAS10270	Q1JH51	-	-
2.7.7.85	Tetragenococcus halophilus	G4L7W3	Pediococcus halophilus	-
2.7.7.85	Tetragenococcus halophilus DSM 20338	G4L7W3	Pediococcus halophilus	-
2.7.7.85	Tetragenococcus halophilus JCM 20259	G4L7W3	Pediococcus halophilus	-
2.7.7.85	Tetragenococcus halophilus NBRC 12172	G4L7W3	Pediococcus halophilus	-
2.7.7.85	Tetragenococcus halophilus NCIMB 9735	G4L7W3	Pediococcus halophilus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2.7.7.85	2 ATP	-	Bacillus subtilis	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Staphylococcus aureus	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus pneumoniae	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus mutans serotype c	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus pyogenes serotype M2	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus equi subsp. zooepidemicus	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Enterococcus faecalis	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus amyloliquefaciens	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus anthracis	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Tetragenococcus halophilus	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium novyi	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium ljungdahlii	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium perfringens	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium botulinum	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Geobacter sulfurreducens	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Listeria monocytogenes EGD	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactococcus cremoris	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lacticaseibacillus rhamnosus	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactobacillus acidophilus	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Tetragenococcus halophilus JCM 20259	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Listeria monocytogenes EGD EGD-e	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactococcus cremoris Sk11	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Staphylococcus aureus NCTC 8325	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus subtilis 168	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Tetragenococcus halophilus DSM 20338	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Tetragenococcus halophilus NCIMB 9735	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium ljungdahlii DSM 13528	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis NCIMB 9375	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Enterococcus faecalis ERV62	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis Gibson 46	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium novyi NT	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium perfringens NCIMB 6125	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium perfringens NCTC 8237	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium perfringens JCM 1290	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis JCM 2505	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus mutans serotype c ATCC 700610	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Tetragenococcus halophilus NBRC 12172	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactococcus cremoris MG1363	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactobacillus acidophilus NCFM	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus pyogenes serotype M2 MGAS10270	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis NRRL NRS-1264	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium perfringens type A	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lacticaseibacillus rhamnosus ATCC 8530	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Geobacter sulfurreducens PCA	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium ljungdahlii PETC	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus pneumoniae ATCC 700669	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Listeria monocytogenes EGD ATCC BAA-679	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactobacillus acidophilus ATCC 700396	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Geobacter sulfurreducens ATCC 51573	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactobacillus acidophilus NCK56	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium perfringens DSM 756	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis NBRC 12200	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Staphylococcus aureus PS 47	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis ATCC 14580	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Lactobacillus acidophilus N2	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Streptococcus mutans serotype c UA159	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Bacillus licheniformis DSM 13	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Clostridium ljungdahlii ATCC 55383	2 diphosphate + cyclic di-3',5'-adenylate	-	?
2.7.7.85	2 ATP	-	Geobacter sulfurreducens DSM 12127	2 diphosphate + cyclic di-3',5'-adenylate	-	?

Subunits

EC Number	Subunits	Comment	Organism
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Bacillus subtilis
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Staphylococcus aureus
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Streptococcus pneumoniae
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Streptococcus mutans serotype c
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Streptococcus pyogenes serotype M2
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Streptococcus equi subsp. zooepidemicus
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Enterococcus faecalis
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Bacillus amyloliquefaciens
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Bacillus licheniformis
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Bacillus anthracis
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Tetragenococcus halophilus
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Clostridium novyi
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Clostridium ljungdahlii
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Clostridium perfringens
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Clostridium botulinum
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Geobacter sulfurreducens
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Listeria monocytogenes EGD
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Lactococcus cremoris
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Lacticaseibacillus rhamnosus
2.7.7.85	homodimer	the dimer-forming CdaA contains three transmembrane domains with the DAC domain (Dis_N Pfam PF02457) located intracellularly, while CdaR contains one transmembrane domain and several YbbR domains (Pfam PF07949) predicted to be located extracellularly	Lactobacillus acidophilus
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Bacillus subtilis
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Staphylococcus aureus
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Streptococcus pneumoniae
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Streptococcus mutans serotype c
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Streptococcus pyogenes serotype M2
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Streptococcus equi subsp. zooepidemicus
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Enterococcus faecalis
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Bacillus amyloliquefaciens
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Bacillus licheniformis
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Bacillus anthracis
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Tetragenococcus halophilus
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Clostridium novyi
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Clostridium ljungdahlii
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Clostridium perfringens
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Clostridium botulinum
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Geobacter sulfurreducens
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Listeria monocytogenes EGD
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Lactococcus cremoris
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Lacticaseibacillus rhamnosus
2.7.7.85	More	the DAC enzyme is organized in the CdaA-CdaR-GlmM protein complex	Lactobacillus acidophilus

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.7.85	CdaA	-	Bacillus subtilis
2.7.7.85	CdaA	-	Staphylococcus aureus
2.7.7.85	CdaA	-	Streptococcus pneumoniae
2.7.7.85	CdaA	-	Streptococcus mutans serotype c
2.7.7.85	CdaA	-	Streptococcus pyogenes serotype M2
2.7.7.85	CdaA	-	Streptococcus equi subsp. zooepidemicus
2.7.7.85	CdaA	-	Enterococcus faecalis
2.7.7.85	CdaA	-	Bacillus amyloliquefaciens
2.7.7.85	CdaA	-	Bacillus licheniformis
2.7.7.85	CdaA	-	Bacillus anthracis
2.7.7.85	CdaA	-	Tetragenococcus halophilus
2.7.7.85	CdaA	-	Clostridium novyi
2.7.7.85	CdaA	-	Clostridium ljungdahlii
2.7.7.85	CdaA	-	Clostridium perfringens
2.7.7.85	CdaA	-	Clostridium botulinum
2.7.7.85	CdaA	-	Geobacter sulfurreducens
2.7.7.85	CdaA	-	Listeria monocytogenes EGD
2.7.7.85	CdaA	-	Lactococcus cremoris
2.7.7.85	CdaA	-	Lacticaseibacillus rhamnosus
2.7.7.85	CdaA	-	Lactobacillus acidophilus
2.7.7.85	Cyclic di-AMP synthase	-	Bacillus subtilis
2.7.7.85	Dac	-	Bacillus subtilis
2.7.7.85	Dac	-	Staphylococcus aureus
2.7.7.85	Dac	-	Streptococcus pneumoniae
2.7.7.85	Dac	-	Streptococcus mutans serotype c
2.7.7.85	Dac	-	Streptococcus pyogenes serotype M2
2.7.7.85	Dac	-	Streptococcus equi subsp. zooepidemicus
2.7.7.85	Dac	-	Enterococcus faecalis
2.7.7.85	Dac	-	Bacillus amyloliquefaciens
2.7.7.85	Dac	-	Bacillus licheniformis
2.7.7.85	Dac	-	Bacillus anthracis
2.7.7.85	Dac	-	Tetragenococcus halophilus
2.7.7.85	Dac	-	Clostridium novyi
2.7.7.85	Dac	-	Clostridium ljungdahlii
2.7.7.85	Dac	-	Clostridium perfringens
2.7.7.85	Dac	-	Clostridium botulinum
2.7.7.85	Dac	-	Geobacter sulfurreducens
2.7.7.85	Dac	-	Listeria monocytogenes EGD
2.7.7.85	Dac	-	Lactococcus cremoris
2.7.7.85	Dac	-	Lacticaseibacillus rhamnosus
2.7.7.85	Dac	-	Lactobacillus acidophilus
2.7.7.85	dacA	-	Bacillus subtilis
2.7.7.85	dacA	-	Staphylococcus aureus
2.7.7.85	dacA	-	Streptococcus pneumoniae
2.7.7.85	dacA	-	Streptococcus mutans serotype c
2.7.7.85	dacA	-	Streptococcus pyogenes serotype M2
2.7.7.85	dacA	-	Streptococcus equi subsp. zooepidemicus
2.7.7.85	dacA	-	Enterococcus faecalis
2.7.7.85	dacA	-	Bacillus amyloliquefaciens
2.7.7.85	dacA	-	Bacillus licheniformis
2.7.7.85	dacA	-	Bacillus anthracis
2.7.7.85	dacA	-	Tetragenococcus halophilus
2.7.7.85	dacA	-	Clostridium novyi
2.7.7.85	dacA	-	Clostridium ljungdahlii
2.7.7.85	dacA	-	Clostridium perfringens
2.7.7.85	dacA	-	Clostridium botulinum
2.7.7.85	dacA	-	Geobacter sulfurreducens
2.7.7.85	dacA	-	Lactococcus cremoris
2.7.7.85	dacA	-	Lactobacillus acidophilus
2.7.7.85	dacA_1	-	Lacticaseibacillus rhamnosus
2.7.7.85	ybbP	-	Streptococcus pneumoniae
2.7.7.85	ybbP	-	Bacillus licheniformis
2.7.7.85	ybbP	-	Bacillus anthracis
2.7.7.85	yedA	-	Listeria monocytogenes EGD

General Information

EC Number	General Information	Comment	Organism
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Bacillus subtilis
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Staphylococcus aureus
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Streptococcus pneumoniae
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Streptococcus mutans serotype c
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Streptococcus pyogenes serotype M2
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Streptococcus equi subsp. zooepidemicus
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Enterococcus faecalis
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Bacillus amyloliquefaciens
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Bacillus licheniformis
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Bacillus anthracis
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Tetragenococcus halophilus
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Clostridium novyi
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Clostridium ljungdahlii
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Clostridium perfringens
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Clostridium botulinum
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Geobacter sulfurreducens
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Listeria monocytogenes EGD
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Lactococcus cremoris
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Lacticaseibacillus rhamnosus
2.7.7.85	metabolism	regulation of diadenylate cyclase activity in bacteria, replenishing the cyclic-di-AMP pool, overview. The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export. Transient regulation of DAC enzyme in the CdaA-CdaR-GlmM protein complex	Lactobacillus acidophilus
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Bacillus subtilis
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Staphylococcus aureus
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Streptococcus pneumoniae
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Streptococcus mutans serotype c
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Streptococcus pyogenes serotype M2
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Streptococcus equi subsp. zooepidemicus
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Enterococcus faecalis
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Bacillus amyloliquefaciens
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Bacillus licheniformis
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Bacillus anthracis
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Tetragenococcus halophilus
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Clostridium novyi
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Clostridium ljungdahlii
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Clostridium perfringens
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Clostridium botulinum
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Geobacter sulfurreducens
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Listeria monocytogenes EGD
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Lactococcus cremoris
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Lacticaseibacillus rhamnosus
2.7.7.85	physiological function	a broadly conserved second messenger is cyclic-di-AMP (c-di-AMP) which regulates a range of processes including cell wall homeostasis, potassium uptake, DNA repair, fatty acid synthesis, biofilm formation and central metabolism in bacteria. Regulators of the membrane-bound enzyme CdaA are the membrane-bound CdaR and the phosphoglucosamine mutase GlmM which both bind directly to the DAC	Lactobacillus acidophilus