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Literature summary extracted from

  • Yang, H.; Shu, Z.; Jiang, Y.; Mao, W.; Pang, L.; Redwood, A.; Jeter-Jones, S.L.; Jennings, N.B.; Ornelas, A.; Zhou, J.; Rodriguez-Aguayo, C.; Bartholomeusz, G.; Iles, L.R.; Zacharias, N.M.; Millward, S.W.; Lopez-Berestein, G.; Le, X.F.; Ahmed, A.A.; Piwnica-Worms, H.; Sood, A.K.; Bast, R.C.; Lu, Z.
    6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase-2 regulates TP53-dependent paclitaxel sensitivity in ovarian and breast cancers (2019), Clin. Cancer Res., 25, 5702-5716 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.105 medicine enzyme inhibition can enhance the effect of paclitaxel-based primary chemotherapy upon ovarian and breast cancers retaining wild type TP53 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate Homo sapiens
-
 ADP + beta-D-fructose 2,6-bisphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Homo sapiens O60825
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 A-2780 cell
-
 Homo sapiens
-
2.7.1.105 breast cancer cell
-
 Homo sapiens
-
2.7.1.105 BT-20 cell
-
 Homo sapiens
-
2.7.1.105 HEY-A8 cell
-
 Homo sapiens
-
2.7.1.105 MCF-7 cell
-
 Homo sapiens
-
2.7.1.105 MDA-MB-231 cell
-
 Homo sapiens
-
2.7.1.105 OC-316 cell
-
 Homo sapiens
-
2.7.1.105 ovary cancer cell
-
 Homo sapiens
-
2.7.1.105 OVCA-8 cell
-
 Homo sapiens
-
2.7.1.105 SKOV3IP cell
-
 Homo sapiens
-
2.7.1.105 ZR-75-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
 Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.1.105 ? x * 55000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.105 PFKFB2 the bifunctional enzyme has 6-phosphofructo-2-kinase and fructose-2,6-biphosphatase activities Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.105 malfunction enzyme knockdown inhibits clonogenic growth and enhances paclitaxel sensitivity in ovarian and breast cancer cell lines with wild type TP53 Homo sapiens
2.7.1.105 physiological function 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-2 regulates TP53-dependent paclitaxel sensitivity in ovarian and breast cancers Homo sapiens