Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hellendahl, K.; Kamel, S.; Wetterwald, A.; Neubauer, P.; Wagner, A.
    Human deoxycytidine kinase is a valuable biocatalyst for the synthesis of nucleotide analogues (2019), Catalysts, 9, 997 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.74 expressed in Escherichia coli BL21 cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.74 Mg2+ 10 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 NTP + deoxycytidine Homo sapiens
-
 NDP + dCMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens P27707
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.74 Ni-NTA column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + fludarabine 53% conversion Homo sapiens ADP + fludarabine 5'-phosphate
-
 ?
2.7.1.74 GTP + arabinosyl-adenine
-
 Homo sapiens GDP + arabinosyl-adenine 5'-phosphate
-
 ?
2.7.1.74 GTP + azacytidine
-
 Homo sapiens GDP + azacytidine 5'-phosphate
-
 ?
2.7.1.74 GTP + cladribine
-
 Homo sapiens GDP + cladribine 5'-phosphate
-
 ?
2.7.1.74 GTP + clofarabine
-
 Homo sapiens GDP + clofarabine 5'-phosphate
-
 ?
2.7.1.74 GTP + fludarabine 54% conversion Homo sapiens GDP + fludarabine 5'-phosphate
-
 ?
2.7.1.74 GTP + gemcitabine
-
 Homo sapiens GDP + gemcitabine 5'-phosphate
-
 ?
2.7.1.74 GTP + lamivudine
-
 Homo sapiens GDP + lamivudine 5'-phosphate
-
 ?
2.7.1.74 additional information the enzyme shows no activity with zidovudine, stavudine, iodoxuridine, thymidine and deoxyuridine Homo sapiens ?
-
-
2.7.1.74 NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?
2.7.1.74 UTP + fludarabine 13% conversion Homo sapiens UDP + fludarabine 5'-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.74 ? x * 34500, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens