Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cirillo, N.; Morgan, D.J.; Pedicillo, M.C.; Celentano, A.; Lo Muzio, L.; McCullough, M.J.; Prime, S.S.
    Characterisation of the cancer-associated glucocorticoid system key role of 11beta-hydroxysteroid dehydrogenase type 2 (2017), Br. J. Cancer, 117, 984-993 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 18beta-glycyrrhetinic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisol + NADP+ Homo sapiens
-
 cortisone + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens P80365
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 DU-145 cell
-
 Homo sapiens
-
1.1.1.146 HaCaT cell
-
 Homo sapiens
-
1.1.1.146 HT-29 cell
-
 Homo sapiens
-
1.1.1.146 HUP-T3 cell
-
 Homo sapiens
-
1.1.1.146 LNCaP cell
-
 Homo sapiens
-
1.1.1.146 MCF-7 cell
-
 Homo sapiens
-
1.1.1.146 melanoma cell
-
 Homo sapiens
-
1.1.1.146 PC-3 cell
-
 Homo sapiens
-
1.1.1.146 RT-4 cell
-
 Homo sapiens
-
1.1.1.146 skin squamous cell carcinoma cell
-
 Homo sapiens
-
1.1.1.146 SW-620 cell
-
 Homo sapiens
-
1.1.1.146 SWH-80 cell
-
 Homo sapiens
-
1.1.1.146 T-24 cell
-
 Homo sapiens
-
1.1.1.146 VCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NADP+
-
 Homo sapiens cortisone + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD2
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.146 Homo sapiens enzyme expression of isoform 11beta-HSD2 is dysregulated in malignant cells down