EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.127 | gene IP3k2, quantitative real-time PCR expression analysis | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.1.127 | additional information | IP3k2 knockdown by siRNA | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | Mg2+ | required | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | - |
ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.127 | Homo sapiens | P27987 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.127 | osteosarcoma cell | - |
Homo sapiens | - |
2.7.1.127 | SAOS-2 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.127 | inositol 1,4,5-trisphosphate kinase 2 | - |
Homo sapiens |
2.7.1.127 | inositol-trisphosphate 3-kinase B | UniProt | Homo sapiens |
2.7.1.127 | IP3K2 | - |
Homo sapiens |
2.7.1.127 | Itpkb | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | ATP | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.7.1.127 | Homo sapiens | the microRNA miR-140-5p inhibits IP3k2 expression in osteosarcoma cells via predicted 3'-UTR target sites and mRNA destabilization. Inhibiting IP3k2 protein expression promotes autophagy in response to anticancer drug treatment | down |
2.7.1.127 | Homo sapiens | IP3K2 expression and Ca2+ entry are upregulated in osteosarcoma cells following treatment with chemotherapeutic drugs, e.g. doxorubicin and cisplatin | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.127 | malfunction | the expression of microRNA-140, termed miR-140-5p, is highly induced during chemotherapy of osteosarcoma cells accompanied by upregulated autophagy. The increased miR-140-5p expression levels upregulate anticancer drug-induced autophagy in osteosarcoma cells and ameliorate the anticancer drug-induced cell proliferation and viability decrease. miR-140-5p regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (IP3k2). miR-140-5p mediated drug-resistance in osteosarcoma cells occurs by inducing autophagy, and miRNA regulation of autophagy through modulation of IP3 signalling. IP3K2 expression and Ca2+ entry are upregulated in osteosarcoma cells following treatment with chemotherapeutic drugs | Homo sapiens |