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Literature summary extracted from

  • Yamamoto, A.; Kurogi, K.; Schiefer, I.T.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Liu, M.C.
    Human cytosolic sulfotransferase SULT1A3 mediates the sulfation of dextrorphan (2016), Biol. Pharm. Bull., 39, 1432-1436 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P0DMM9 isoform SULT1A3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 Caco-2 cell
-
 Homo sapiens
-
2.8.2.1 Hep-G2 cell
-
 Homo sapiens
-
2.8.2.1 liver
-
 Homo sapiens
-
2.8.2.1 lung
-
 Homo sapiens
-
2.8.2.1 small intestine
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.1 0.00194
-
 substrate dextrorphan, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.00293
-
 substrate 4-nitrophenol, pH 7.0, 37°C Homo sapiens
2.8.2.1 0.0781
-
 substrate dopamine, pH 7.0, 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + dextrorphan i.e. active metabolite of the antitussive dextromethorphan Homo sapiens adenosine 3',5'-bisphosphate + dextrorphan sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + dopamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1A3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.8.2.1 metabolism of all thirteen known human SULTs, isoform SULT1A3 displays the strongest dextrorphan-sulfating activity Homo sapiens