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Literature summary extracted from

  • Fernius, J.; Starkenberg, A.; Pokrzywa, M.; Thor, S.
    Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau (2017), Biol. Open, 6, 113-1023 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.26 ATP + tau-protein Drosophila melanogaster phosphorylation at Ser-422 ADP + O-phospho-tau-protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.26 neuron
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + tau-protein phosphorylation at Ser-422 Drosophila melanogaster ADP + O-phospho-tau-protein
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.26 ? x * 180000, isoform TTBK1, SDS-PAGE Drosophila melanogaster
2.7.11.26 ? x * 180000, isoform TTBK2, SDS-PAGE Drosophila melanogaster
2.7.11.26 ? x * 200000, isoform MARK1, SDS-PAGE Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 MARK1
-
 Drosophila melanogaster
2.7.11.26 Tau tubulin binding kinase1
-
 Drosophila melanogaster
2.7.11.26 Tau tubulin binding kinase2
-
 Drosophila melanogaster
2.7.11.26 Tau-kinase
-
 Drosophila melanogaster
2.7.11.26 TTBK1
-
 Drosophila melanogaster
2.7.11.26 TTBK2
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.11.26 physiological function the tau-kinases MARK1, TTBK1, TTBK2 reduce lifespan of Drosophila melanogaster, and the effects are increased by co expression with human tau-protein Drosophila melanogaster