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Literature summary extracted from

  • Ferrante, T.; Adinolfi, S.; DArrigo, G.; Poirier, D.; Daga, M.; Lolli, M.L.; Balliano, G.; Spyrakis, F.; Oliaro-Bosso, S.
    Multiple catalytic activities of human 17beta-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors (2020), Biochimie, 170, 106-117 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.62 overexpression in Escherichia coli BL21 (DE3) Homo sapiens
1.1.1.62 overexpression in Escherichia coli BL21 (DE3) Codon Plus RP cells Homo sapiens
1.1.1.270 overexpression in Escherichia coli BL21 (DE3) Codon Plus RP cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.62 (4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
-
 Homo sapiens
1.1.1.62 (4aR,6aS,7S)-7-[heptyl(methyl)amino]-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
-
 Homo sapiens
1.1.1.62 17beta-[(N-decyl)formamido]-4-aza-5alpha-androstan-3-one
-
 Homo sapiens
1.1.1.62 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
-
 Homo sapiens
1.1.1.62 17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one
-
 Homo sapiens
1.1.1.62 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
-
 Homo sapiens
1.1.1.62 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
-
 Homo sapiens
1.1.1.62 N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
-
 Homo sapiens
1.1.1.62 N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
-
 Homo sapiens
1.1.1.62 N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.62 estrone + NADPH + H+ Homo sapiens steroid hormone pathway 17beta-estradiol + NAD(P)+
-
 ?
1.1.1.270 (4-methyl)zymosterone + NADPH + H+ Homo sapiens cholesterol pathway (4-methyl)zymosterol + NADP+
-
 ?
1.1.1.270 dihydrotestosterone + NADPH + H+ Homo sapiens steroid hormone pathway 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.270 progesterone + NADPH + H+ Homo sapiens steroid hormone pathway 4-pregnen-3beta-ol-20-one + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens P56937
-
-
1.1.1.270 Homo sapiens P56937
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 dihydrotestosterone + NADPH + H+
-
 Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.62 estrone + NADPH + H+
-
 Homo sapiens estradiol + NADP+
-
 ?
1.1.1.62 estrone + NADPH + H+
-
 Homo sapiens 17beta-estradiol + NAD(P)+
-
 ?
1.1.1.62 estrone + NADPH + H+ steroid hormone pathway Homo sapiens 17beta-estradiol + NAD(P)+
-
 ?
1.1.1.62 progesterone + NADPH + H+
-
 Homo sapiens 4-preggnen-3beta-ol-20-one + NADP+
-
 ?
1.1.1.270 (4-methyl)zymosterone + NADPH + H+
-
 Homo sapiens (4-methyl)zymosterol + NADP+
-
 ?
1.1.1.270 (4-methyl)zymosterone + NADPH + H+ cholesterol pathway Homo sapiens (4-methyl)zymosterol + NADP+
-
 ?
1.1.1.270 dihydrotestosterone + NADPH + H+
-
 Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.270 dihydrotestosterone + NADPH + H+ steroid hormone pathway Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.270 progesterone + NADPH + H+
-
 Homo sapiens 4-pregnen-3beta-ol-20-one + NADP+
-
 ?
1.1.1.270 progesterone + NADPH + H+ steroid hormone pathway Homo sapiens 4-pregnen-3beta-ol-20-one + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.62 17beta-hydroxysteroid dehydrogenase type 7
-
 Homo sapiens
1.1.1.62 HSD17B7
-
 Homo sapiens
1.1.1.270 HSD17B7
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.62 0.00041
-
 pH and temperature not specified in the publication Homo sapiens (4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
1.1.1.62 0.00041
-
 pH 7.4, 37°C, reduction of estrone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.0006
-
 pH and temperature not specified in the publication, substrate: progesterone Homo sapiens (4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
1.1.1.62 0.0006
-
 pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.0007
-
 pH and temperature not specified in the publication Homo sapiens N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
1.1.1.62 0.0007
-
 pH 7.4, 37°C, reduction of estrone Homo sapiens 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00096
-
 pH and temperature not specified in the publication Homo sapiens (4aR,6aS,7S)-7-[heptyl(methyl)amino]-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
1.1.1.62 0.00112
-
 pH and temperature not specified in the publication Homo sapiens N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
1.1.1.62 0.00119
-
 pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00291
-
 pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
1.1.1.62 0.00291
-
 pH 7.4, 37°C, reduction of estrone Homo sapiens 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00316
-
 pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00332
-
 pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
1.1.1.62 0.00332
-
 pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00396
-
 pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
1.1.1.62 0.00396
-
 pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00424
-
 pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00578
-
 pH and temperature not specified in the publication, substrate: progesterone Homo sapiens N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
1.1.1.62 0.00578
-
 pH 7.4, 37°C, reduction of dihydrotestosterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one
1.1.1.62 0.00601
-
 pH 7.4, 37°C, reduction of progesterone Homo sapiens 17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one

General Information

EC Number General Information Comment Organism
1.1.1.62 physiological function the enzyme is involved in the metabolism of steroid hormones and in the biosynthesis of cholesterol Homo sapiens
1.1.1.270 physiological function the enzyme is involved in the metabolism of steroid hormones and in the biosynthesis of cholesterol Homo sapiens