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Literature summary extracted from

  • Kumar, R.; Ahmad, F.; Rathaur, S.
    Characterization of filarial phosphoglycerate kinase (2019), Biochimie, 165, 258-266 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.2.3 Calmodulin a significant increase (1.8 times) in enzyme activity is observed in the co-presence of calmodulin (0.001 mM) and CaCl2 (0.01 mM). The enzyme activity remains unaltered in the presence of either calcium or calmodulin alone Brugia malayi
2.7.2.3 Calmodulin the enzyme is activated up to 85% in the presence of 0.001 mM calmodulin Setaria cervi

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.3
-
 Brugia malayi

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.3 Ca2+ 5.0 mM Ca2+ results in 40% inhibition of activity Setaria cervi
2.7.2.3 EDTA
-
 Brugia malayi
2.7.2.3 EDTA
-
 Setaria cervi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.2.3 Ca2+ a significant increase (1.8 times) in enzyme activity is observed in the co-presence of calmodulin (0.001 mM) and CaCl2 (0.01 mM). The enzyme activity remains unaltered in the presence of either calcium or calmodulin alone Brugia malayi
2.7.2.3 Ca2+ the enzyme is activated up to 85% in the presence of 0.01 mM Ca2+ Setaria cervi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.3 ATP + 3-phospho-D-glycerate Setaria cervi
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 ATP + 3-phospho-D-glycerate Brugia malayi
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.3 Brugia malayi A0A0H5S3P5
-
-
2.7.2.3 Brugia malayi A0A4E9EYJ5
-
-
2.7.2.3 Setaria cervi A0A0M4FXK5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.2.3 Ni-NTA column chromatography Brugia malayi

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.2.3 adult
-
 Setaria cervi
-
2.7.2.3 adult
-
 Brugia malayi
-
2.7.2.3 microfilarial stage highest expression Setaria cervi
-
2.7.2.3 microfilarial stage highest expression Brugia malayi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.3 ATP + 3-phospho-D-glycerate
-
 Setaria cervi ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
2.7.2.3 ATP + 3-phospho-D-glycerate
-
 Brugia malayi ADP + 3-phospho-D-glyceroyl phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.2.3 ? x * 45000, SDS-PAGE Brugia malayi

Synonyms

EC Number Synonyms Comment Organism
2.7.2.3 PGK
-
 Setaria cervi
2.7.2.3 PGK
-
 Brugia malayi