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Literature summary extracted from

  • Sakai, H.; Murakami, C.; Matsumoto, K.I.; Urano, T.; Sakane, F.
    Diacylglycerol kinase delts controls down-regulation of cyclin D1 for C2C12 myogenic differentiation (2018), Biochimie, 151, 45-53 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Mus musculus
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Mus musculus E9PUQ8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 C2C12 cell
-
 Mus musculus
-
2.7.1.107 myoblast
-
 Mus musculus
-
2.7.1.107 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
 Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKdelta isoform Mus musculus
2.7.1.107 diacylglycerol kinase delta isoform Mus musculus

Expression

EC Number Organism Comment Expression
2.7.1.107 Mus musculus DGKdelta expression is down-regulated in the early stage of C2C12 myogenic differentiation down

General Information

EC Number General Information Comment Organism
2.7.1.107 malfunction the suppression of DGKdelta expression increases the phosphorylation levels of conventional and novel protein kinase C (cnPKCs). Furthermore, DGKdelta suppression increases the levels of cyclin D1 and phospho-cnPKCs even at the first 24 h of myogenic differentiation Mus musculus
2.7.1.107 physiological function isoform DGKdelta regulates the early differentiation of C2C12 myoblasts via controlling the down-regulation of cyclin D1 expression Mus musculus