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Literature summary extracted from

  • Ayikpoe, R.; Salazar, J.; Majestic, B.; Latham, J.A.
    Mycofactocin biosynthesis proceeds through 3-amino-5-[( p-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); direct observation of MftE specificity toward MftA (2018), Biochemistry, 57, 5379-5383 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.14 Fe2+ dependent on Mycolicibacterium smegmatis
3.4.14.14 Fe2+ dependent on Mycobacterium ulcerans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.14.14 additional information Mycolicibacterium smegmatis the enzyme does not recognize the unmodified peptide MftA nor the intermediate MftA-glycyl-N-[(E)-2-(4-hydroxyphenyl)ethenyl]-L-valinamide ?
-
-
3.4.14.14 additional information Mycobacterium ulcerans the enzyme does not recognize the unmodified peptide MftA nor the intermediate MftA-glycyl-N-[(E)-2-(4-hydroxyphenyl)ethenyl]-L-valinamide ?
-
-
3.4.14.14 precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O Mycolicibacterium smegmatis the enzyme is specific for MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?
3.4.14.14 precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O Mycobacterium ulcerans the enzyme is specific for MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.14 Mycobacterium ulcerans
-
-
-
3.4.14.14 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.14 additional information the enzyme does not recognize the unmodified peptide MftA nor the intermediate MftA-glycyl-N-[(E)-2-(4-hydroxyphenyl)ethenyl]-L-valinamide Mycolicibacterium smegmatis ?
-
-
3.4.14.14 additional information the enzyme does not recognize the unmodified peptide MftA nor the intermediate MftA-glycyl-N-[(E)-2-(4-hydroxyphenyl)ethenyl]-L-valinamide Mycobacterium ulcerans ?
-
-
3.4.14.14 precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O the enzyme is specific for MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one Mycolicibacterium smegmatis MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?
3.4.14.14 precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O the enzyme is specific for MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one Mycobacterium ulcerans MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.14 mftE
-
 Mycolicibacterium smegmatis
3.4.14.14 mftE
-
 Mycobacterium ulcerans