Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Oudouhou, F.; Casu, B.; Dopgwa Puemi, A.S.; Sygusch, J.; Baron, C.
    Analysis of Novel interactions between components of the selenocysteine biosynthesis pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43 (2017), Biochemistry, 56, 2261-2270 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.9.3 ATP + selenide + H2O Homo sapiens
-
 AMP + selenophosphate + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate + H2O Homo sapiens
-
 L-selenocysteinyl-tRNASec + 2 phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.9.3 Homo sapiens Q99611
-
-
2.9.1.2 Homo sapiens Q9HD40
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.9.3 HEK-293T cell
-
 Homo sapiens
-
2.9.1.2 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.9.3 ATP + selenide + H2O
-
 Homo sapiens AMP + selenophosphate + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate + H2O
-
 Homo sapiens L-selenocysteinyl-tRNASec + 2 phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.9.3 oligomer selenocysteine synthase (SEPSECS), SECp43, and selenophosphate synthetases SEPHS1 and SEPHS2 form oligomers in eukaryotic cells Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.9.3 Sephs2
-
 Homo sapiens
2.9.1.2 Selenocysteine synthase
-
 Homo sapiens
2.9.1.2 SepSecS
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.9.3 physiological function SEPHS2 is responsible for de novo synthesis of monoselenophosphate. SEPHS2 interacts with SEPSECS and SEPHS1 Homo sapiens
2.9.1.2 metabolism in mammalian cells, the incorporation of the 21st amino acid, selenocysteine, into proteins is guided by the Sec machinery. The function of this protein complex requires several protein?protein and protein?RNA interactions, leading to the incorporation of selenocysteine at UGA codons. It is guided by stem?loop structures localized in the 3? untranslated regions of the selenoprotein-encoding genes Homo sapiens