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Literature summary extracted from

  • Noguchi, S.; Kondo, Y.; Ito, R.; Katayama, T.; Kazama, S.; Kadota, Y.; Kitaura, Y.; Harris, R.A.; Shimomura, Y.
    Ca2+-dependent inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate (2018), Biochem. Biophys. Res. Commun., 504, 916-920 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.4 thiamine diphosphate Ca2+-dependent inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.4 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] Rattus norvegicus
-
 ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Rattus norvegicus Q00972 male Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]
-
 Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.4 BDK
-
 Rattus norvegicus
2.7.11.4 branched-chain alpha-ketoacid dehydrogenase kinase
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.4 0.0025
-
 pH 7.4, 30°C, in the presence of 0.001 mM Ca2+ Rattus norvegicus thiamine diphosphate