Literature summary extracted from
Rivelli, J.F.; Ochoa, A.L.; Santander, V.S.; Nigra, A.; Previtali, G.; Casale, C.H.
Regulation of aldose reductase activity by tubulin and phenolic acid derivates (2018), Arch. Biochem. Biophys., 654, 19-26 .
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.1.1.21 |
3,4-dihydroxyphenylacetic acid |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
1.1.1.21 |
3-hydroxy-4-methoxymandelic acid |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
1.1.1.21 |
3-nitro-L-tyrosine |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
1.1.1.21 |
4-hydroxy-3-methoxymandelic acid |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
1.1.1.21 |
4-hydroxy-3-methoxyphenylacetic acid |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
1.1.1.21 |
4-hydroxy-3-methoxyphenyllactic acid |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
1.1.1.21 |
L-tyrosine |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
1.1.1.21 |
vanillic acid |
able to prevent the formation of the tubulin/aldose reductase complex and the activation of aldose reductase by tubulin |
Homo sapiens |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.1.1.21 |
Homo sapiens |
P15121 |
- |
- |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.1.1.21 |
physiological function |
aldose reductase interacts directly with tubulin and has greater affinity for 3-nitro-tyrosinated tubulin. Free 3-nitro-Tyr or Tyr prevents tubulin/aldose reductase complex formation and aldose reductase activation. The induction of microtubule formation by high concentrations of glucose and the consequent activation of aldose reductase in cultured cells can be inhibited by phenolic acid derivates that prevent the interaction tubulin/aldose reductase |
Homo sapiens |