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Literature summary extracted from

  • Zmuda, F.; Shepherd, S.; Ferguson, M.; Gray, D.; Torrie, L.; De Rycker, M.
    Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment (2019), Antimicrob. Agents Chemother., 63, e01082-19 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.13 expressed in Escherichia coli BL21(DE3) cells Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.13 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutanoic acid
-
 Trypanosoma cruzi
2.7.7.13 3-(azetidin-1-yl)-N-(imidazo[1,2-a]pyridin-3-ylmethyl)propan-1-amine
-
 Trypanosoma cruzi
2.7.7.13 4-[3-(3-aminopyrrolidin-1-yl)propoxy]benzoic acid
-
 Trypanosoma cruzi
2.7.7.13 5-(2-amino-1,3-thiazol-4-yl)-2-hydroxybenzyl acetate
-
 Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.13 0.0133
-
 alpha-D-mannose 1-phosphate at pH 7.5 and 25°C Trypanosoma cruzi
2.7.7.13 0.0407
-
 GTP at pH 7.5 and 25°C Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.13 GTP + alpha-D-mannose 1-phosphate Trypanosoma cruzi
-
 diphosphate + GDP-mannose
-
 r
2.7.7.13 GTP + alpha-D-mannose 1-phosphate Trypanosoma cruzi CL Brener
-
 diphosphate + GDP-mannose
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.13 Trypanosoma cruzi Q4CMK4
-
-
2.7.7.13 Trypanosoma cruzi CL Brener Q4CMK4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.13 HisTrap Ni affinity column chromatography and Superdex 200 gel filtration Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.13 GTP + alpha-D-mannose 1-phosphate
-
 Trypanosoma cruzi diphosphate + GDP-mannose
-
 r
2.7.7.13 GTP + alpha-D-mannose 1-phosphate
-
 Trypanosoma cruzi CL Brener diphosphate + GDP-mannose
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.7.13 hexamer
-
 Trypanosoma cruzi

Synonyms

EC Number Synonyms Comment Organism
2.7.7.13 GDP-mannose pyrophosphorylase
-
 Trypanosoma cruzi
2.7.7.13 GDP-MP
-
 Trypanosoma cruzi
2.7.7.13 guanosine diphosphate-mannose pyrophosphorylase
-
 Trypanosoma cruzi