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Literature summary extracted from

  • Looker, H.C.; Merchant, M.L.; Rane, M.J.; Nelson, R.G.; Kimmel, P.L.; Rovin, B.H.; Klein, J.B.; Mauer, M.; Mauer, M.
    Urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes (2018), Am. J. Physiol. Renal Physiol., 315, F1484-F1492 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.158 diagnostics assessing early kidney structural damage in diabetic kidney disease (DKD) via a urine biomarker is an appealing goal, and IPP2K may be a promising candidate Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.158 recombinant expression of His-tagged enzyme in Escherichia coli strain BL21 (Lys) DE3 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.158 cytoplasm
-
 Homo sapiens 5737
-
2.7.1.158 additional information IPP2K is present in cell nuclei, where it colocalizes with mRNA in the nucleoli, whereas in the cytoplasm it is found principally in stress granules. Distribution of baseline urine inositol 1,3,4,5,6-pentakisphosphate 2-kinase/creatinine (IPP2K/Cr) in women and men, overview Homo sapiens
-
-
2.7.1.158 nucleolus
-
 Homo sapiens 5730
-
2.7.1.158 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.158 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol hexakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.158 Homo sapiens Q9H8X2
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.158 recombinant His-tagged enzyme from Escherichia coli strain BL21 (Lys) DE3 by nickel affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.158 kidney
-
 Homo sapiens
-
2.7.1.158 urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol hexakisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.158 More peptide mapping, quantitative LC-selective reaction monitoring-MS (LC-SRM-MS) analysis Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.158 inositol pentakisphosphate 2-kinase
-
 Homo sapiens
2.7.1.158 IPP2K
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.158 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.158 malfunction urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes. A higher prevalence of detectable urinary inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPP2K) in type 1 diabetes correlates with early renal function decline. Proximal tubule cells from people with type 1 diabetes and diabetic kidney disease (DKD) express more IPP2K compared with controls. Demographics and clinical characteristics by tertile of baseline urine inositol 1,3,4,5,6-pentakisphosphate 2-kinase/creatinine (IPP2K/Cr), overview Homo sapiens
2.7.1.158 physiological function association of urine inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPP2K) with the presence and progression of diabetic kidney disease (DKD) lesions. Inositol 6-phosphate is a key intracellular signaling molecule with roles in mRNA editing and chromatin remodeling Homo sapiens