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Literature summary extracted from

  • Zheng, H.; Yu, M.; Pu, C.; Chen, M.; Li, F.; Shen, Y.; Huang, L.
    Cloning and expression analysis of 5-phosphomevalonate kinase gene (CcPMK) in Cinnamomum camphora (2020), Zhongguo Zhong Yao Za Zhi, 45, 78-84 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.2 gene CcPMK, DNA and amino acid sequence determination and analysis, cDNA on the basis of the transciptome database of Cinnamomum camphora, sequence comparison and phylogenetic analysis Cinnamomum camphora

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.2 additional information sequence analysis reveals no signal peptide and transmembrane structure in the putative protein Cinnamomum camphora
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.2 Mg2+ required Cinnamomum camphora

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.2 ATP + (R)-5-phosphomevalonate Cinnamomum camphora
-
 ADP + (R)-5-diphosphomevalonate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.2 Cinnamomum camphora A0A6G6C941
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.2 branch low expression level Cinnamomum camphora
-
2.7.4.2 additional information results of real-time PCR indicate that the expression level of CcPMK in borneol type is higher than that in linalool type, cineol type, iso-nerolidol type, and camphor type variants of Cinnamomum camphora trees. CcPMK expressed highest in roots and lowest in branches Cinnamomum camphora
-
2.7.4.2 root high expression level Cinnamomum camphora
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.2 ATP + (R)-5-phosphomevalonate
-
 Cinnamomum camphora ADP + (R)-5-diphosphomevalonate
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.4.2 ? x * 56140, sequence calculation Cinnamomum camphora
2.7.4.2 More Cinnamomum camphora PMK has 3 PMK protein family motifs and 1 ATP binding site Gly-Leu-Gly-Ser-Ser-Ala-Ala, and its 3D structure contains a catalytic pocket structure, proving CcPMK as a member of PMK gene family Cinnamomum camphora

Synonyms

EC Number Synonyms Comment Organism
2.7.4.2 CcPMK
-
 Cinnamomum camphora
2.7.4.2 PMK
-
 Cinnamomum camphora

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.4.2 Cinnamomum camphora sequence calculation
-
 7.64

General Information

EC Number General Information Comment Organism
2.7.4.2 evolution Cinnamomum camphora PMK has 3 PMK protein family motifs and 1 ATP binding site Gly-Leu-Gly-Ser-Ser-Ala-Ala, and its 3 D structure contains a catalytic pocket structure, proving CcPMK as a member of PMK gene family Cinnamomum camphora
2.7.4.2 physiological function the 5-phosphomevalonate kinase(PMK) is a key enzyme in mevalonate(MVA) pathway which reversibly catalyzes the phosphorylation of mevalonate 5-phosphate(MVAP) to form mevalonate-5-diphosphate(MVAPP) in the presence of ATP and divalent metal ion such as Mg2+. The expression level of CcPMK was different among five chemical types and different plant tissues Cinnamomum camphora