Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yu, H.; Xiang, P.; Pan, Q.; Huang, Y.; Xie, N.; Zhu, W.
    Ubiquitin-conjugating enzyme E2T is an independent prognostic factor and promotes gastric cancer progression (2016), Tumour Biol., 37, 11723-11732 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.2.23 diagnostics ubiquitin-conjugating enzyme E2T is an independent prognostic factor and promotes gastric cancer progression Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.23 gene UBE2T, located in chromosome 1q32.1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.23 additional information knockdown of enzyme UBE2T by specific siRNA in BGC-823 cells and HTB-103 cells can induce G1/S phase arrest in gastric cancer cells, which in turn contributes to the stimulating growth properties of gastric cancer cells. Overexpression of UBE2T in AGS cells and CRL-5974 cells. Phenotypes, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.23 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine Homo sapiens
-
 [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.23 Homo sapiens Q9NPD8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.23 AGS cell
-
 Homo sapiens
-
2.3.2.23 BGC-823 cell
-
 Homo sapiens
-
2.3.2.23 gastric cancer cell quantitative real-time PCR enzyme expression analysis in gastric cancer cell lines, overview Homo sapiens
-
2.3.2.23 HGC-27 cell
-
 Homo sapiens
-
2.3.2.23 KATO-III cell
-
 Homo sapiens
-
2.3.2.23 MGC-803 cell
-
 Homo sapiens
-
2.3.2.23 MKN-45 cell
-
 Homo sapiens
-
2.3.2.23 SGC-7901 cell
-
 Homo sapiens
-
2.3.2.23 SNU-1 cell
-
 Homo sapiens
-
2.3.2.23 SNU-16 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.23 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 Homo sapiens [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.23 UBE2T
-
 Homo sapiens
2.3.2.23 ubiquitin-conjugating enzyme E2T
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.23 evolution ubiquitin-conjugating enzyme E2T (UBE2T) is a member of the E2 family that mediates the ubiquitin-proteasome system and regulates gene expression Homo sapiens
2.3.2.23 malfunction UBE2T downregulation induces gastric cancer cell cycle arrest Homo sapiens
2.3.2.23 physiological function enzyme UBE2T promotes cell proliferation and inhibits cell cycle arrest. In addition, UBE2T modulates cell mobility by inducing epithelial-mesenchymal transition. UBE2T plays an important role in the tumorigenesis of gastric cancer, it promotes tumor cell growth and metastasis. UBE2T has been reported to be recruited independently to regulate FANCD2 monoubiquitination and participates in the Fanconi anemia pathway together with FANCD2 Homo sapiens