EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.7.48 | remdesivir | cryo-electron microscopy structure of the SARS-CoV-2 RNA-dependent RNA polymerase, both in the apo form at 2.8 A resolution and in complex with a 50-base template-primer RNA and remdesivir at 2.5 A resolution. The complex structure reveals that the partial double-stranded RNA template is inserted into the central channel of the RNA-dependent RNA polymerase, where remdesivir is covalently incorporated into the primer strand at the first replicated base pair, and terminates chain elongation | Severe acute respiratory syndrome coronavirus 2 |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | Severe acute respiratory syndrome coronavirus 2 | - |
diphosphate + RNAn+1 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.48 | Severe acute respiratory syndrome coronavirus 2 | P0DTD1 | replicase polyprotein 1ab; SARS-CoV-2 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | - |
Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.48 | RDRP | - |
Severe acute respiratory syndrome coronavirus 2 |
2.7.7.48 | RNA-dependent RNA polymerase | - |
Severe acute respiratory syndrome coronavirus 2 |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.7.48 | drug target | cryo-electron microscopy structure of the SARS-CoV-2 RNA-dependent RNA polymerase provides insights into the mechanism of viral RNA replication and a rational template for drug design to combat the viral infection | Severe acute respiratory syndrome coronavirus 2 |