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Literature summary extracted from

  • Jayawickrama, G.S.; Nematollahi, A.; Sun, G.; Gorrell, M.D.; Church, W.B.
    Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives (2017), Sci. Rep., 7, 17559 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 BFF-122 irreversible inhibitor; irreversible inhibitor Homo sapiens
2.6.1.7 BFF-816 reversible inhibitor; reversible inhibitor Homo sapiens
2.6.1.7 estradiol disulfate strong reversible inhibitor; strong reversible inhibitor Homo sapiens
2.6.1.7 Estrone sulfate weak inhibitor Homo sapiens
2.6.1.7 additional information not inhibited by estradiol and estradiol 3-sulfate; not inhibited by estrone sulfate, estradiol and estradiol 3-sulfate Homo sapiens
2.6.1.7 NS-1502 reversible inhibitor; reversible inhibitor Homo sapiens
2.6.1.7 PF-04859989 irreversible inhibitor; irreversible inhibitor Homo sapiens
2.6.1.7 S-4-(ethylsulfonyl)benzoyl-L-alanine reversible inhibitor; reversible inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate Homo sapiens
-
 kynurenic acid + L-glutamate + H2O
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Homo sapiens Q16773
-
-
2.6.1.7 Homo sapiens Q8N5Z0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.7 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate
-
 Homo sapiens kynurenic acid + L-glutamate + H2O
-
 ir

Subunits

EC Number Subunits Comment Organism
2.6.1.7 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.6.1.7 KAT-I isoform Homo sapiens
2.6.1.7 KAT-II isoform Homo sapiens
2.6.1.7 kynurenine aminotransferase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.7 0.0263
-
 isoform KAT-II, at pH 7.4 and 37°C Homo sapiens estradiol disulfate
2.6.1.7 0.2915
-
 isoform KAT-I, at pH 7.4 and 37°C Homo sapiens estradiol disulfate