EC Number | Organism | UniProt | Comment | Textmining |
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2.5.1.47 | Leishmania donovani | G1C2I2 | - |
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EC Number | General Information | Comment | Organism |
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2.5.1.47 | physiological function | overexpression of cysteine synthase in amphotericin B (Amp B) sensitive strain S1-OE modulates resistance towards oxidative stress and drug pressure. Antioxidant enzyme activities are upregulated in S1-OE parasites and these parasites alleviate intracellular reactive oxygen species efficiently by maintaining the reduced thiol pool. The Amp B sensitive strain shows higher levels of reactive oxygen species which is positively correlated with the protein carbonylation levels and negatively correlated with cell viability. Cysteine synthase overexpression also augments the ROS-primed induction of cysteine synthase-GFP as well as endogenous cysteine synthase and thiol pathway proteins in Leishmania donovani parasites. The expression of cysteine synthase is upregulated in Amp B resistant isolates and during infective stationary stages of growth. Cysteine synthase overexpression enhances the infectivity of Leishmania donovani parasites | Leishmania donovani |