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Literature summary extracted from

  • Heydel, J.M.; Menetrier, F.; Belloir, C.; Canon, F.; Faure, P.; Lirussi, F.; Chavanne, E.; Saliou, J.M.; Artur, Y.; Canivenc-Lavier, M.C.; Briand, L.; Neiers, F.
    Characterization of rat glutathione transferases in olfactory epithelium and mucus (2019), PLoS ONE, 14, e0220259 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.18 expressed in Escherichia coli BL21(DE3) cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 (+)-limonene oxide about 85% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 (-)-limonene oxide about 15% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 (R)-carvone about 8% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 2,4,6-trichloroanisole about 5% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 2-butanethiol about 2% inhibition at 0.01 mM Rattus norvegicus
2.5.1.18 beta-ionone about 15% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 cinnamaldehyde about 60% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 citral about 25% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 cyclohexanone about 3% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 Dimethyl sulfide about 5% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 geraniol about 3% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 geranyl acetate about 5% inhibition at 0.01 mM Rattus norvegicus
2.5.1.18 hexanoic acid about 5% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 limonene oxide about 70% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 mesityl oxide about 5% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 additional information not inhibited by 6-methyl-5-hepten-2-one Rattus norvegicus
2.5.1.18 S-carvone S-carvone inhibits 26% of the enzyme activity at 0.01 mM and 84% at 0.1 mM Rattus norvegicus
2.5.1.18 trans-2-hexen-1-al about 23% inhibition at 0.1 mM Rattus norvegicus
2.5.1.18 trans-2-nonenal about 23% inhibition at 0.01 mM Rattus norvegicus
2.5.1.18 Vanillin less than 10% inhibition at 0.1 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Rattus norvegicus P08010
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18 GST Trap column chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 nasal mucosa
-
 Rattus norvegicus
-
2.5.1.18 olfactory epithelium
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus chloride + 2,4-dinitrophenyl-glutathione
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.18 ? x * about 30000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.5.1.18 glutathione S-transferase
-
 Rattus norvegicus
2.5.1.18 GSTM2 isoform Rattus norvegicus