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Literature summary extracted from

  • Hayat, F.; Migaud, M.E.
    Nicotinamide riboside-amino acid conjugates that are stable to purine nucleoside phosphorylase (2020), Org. Biomol. Chem., 18, 2877-2885 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.1 1,5-O-bis(N-benzyloxycarbonylglycyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens
2.4.2.1 1-[2,3-O-isopropylidene-D-ribofuranosyl]-1,4-dihydropyridine-3-carboxamide
-
 Homo sapiens
2.4.2.1 3-carbamoyl-1-[2,3-O-isopropylidene-D-ribofuranosyl]pyridin-1-ium
-
 Homo sapiens
2.4.2.1 nicotinamide 5-O-glycyl-beta-D-riboside
-
 Homo sapiens
2.4.2.1 nicotinamide 5-O-L-isoleucyl-beta-D-riboside
-
 Homo sapiens
2.4.2.1 nicotinamide 5-O-L-leucyl-beta-D-riboside
-
 Homo sapiens
2.4.2.1 nicotinamide 5-O-L-methionyl-beta-D-riboside
-
 Homo sapiens
2.4.2.1 nicotinamide 5-O-L-tryptophanyl-beta-D-riboside
-
 Homo sapiens
2.4.2.1 nicotinamide 5-O-L-tyrosinyl-beta-D-riboside
-
 Homo sapiens
2.4.2.1 nicotinamide 5-O-L-valyl-beta-D-riboside
-
 Homo sapiens
2.4.2.1 reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-isoleucyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens
2.4.2.1 reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-leucyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens
2.4.2.1 reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-methionyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens
2.4.2.1 reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-tyrosinyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens
2.4.2.1 reduced nicotinamide 5-O-(N-tert-butyloxycarbonyl-L-valyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens
2.4.2.1 reduced nicotinamide 5-O-(N-tert-butyloxycarbonylglycyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens
2.4.2.1 reduced nicotinamide 5-O-(N1,Nalpha-bis(tert-butyloxycarbonyl)-L-tryptophanyl)-2,3-O-isopropylidene beta-D-riboside
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.1 Homo sapiens P00491
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.1 additional information the nutraceutical nicotinamide riboside (NR), an efficacious biosynthetic precursor to NAD, is readily metabolized by the purine nucleoside phosphorylase (PNP). Access to the PNP-stable versions of NR is difficult because the glycosidic bond of NR is easily cleaved. Unlike NR, NRH, the reduced form of NR, offers sufficient chemical stability to allow the successful functionalisation of the ribosyl-moiety. A series of NRH and NR derived amino acid conjugates is generated in good to excellent yields and show that O5'-esterification prevents the PNP-catalyzed phosphorolysis of these NR prodrugs, overview. Enzyme PNP catalyzes the phosphorolysis of nicotinamide riboside chloride (NR-Cl) and glycine nicotinamide riboside conjugate (Gly-NR) Homo sapiens ?
-
-
2.4.2.1 nicotinamide riboside + phosphate
-
 Homo sapiens nicotinamide + alpha-D-ribose 1-phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.4.2.1 PNP
-
 Homo sapiens
2.4.2.1 purine nucleoside phosphorylase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.1 22
-
 assay at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.1 7
-
 assay at Homo sapiens