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Literature summary extracted from

  • Chotpatiwetchkul, W.; Boonyarattanakalin, K.; Gleeson, D.; Gleeson, M.P.
    Exploring the catalytic mechanism of dihydropteroate synthase elucidating the differences between the substrate and inhibitor (2017), Org. Biomol. Chem., 15, 5593-5601 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Yersinia pestis
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diphosphate + 7,8-dihydropteroate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Yersinia pestis A0A384KP04
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
Yersinia pestis diphosphate + 7,8-dihydropteroate
-
?
2.5.1.15 (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate mechanistic proposals for dihydropteroate synthase have been systematically investigated using a hybrid QM/MM method. A reaction mechanism is proposed that follows an SN1 process with the rate determining step being C-O bond breaking to give a carbocation intermediate Yersinia pestis diphosphate + 7,8-dihydropteroate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 DHPS
-
Yersinia pestis

General Information

EC Number General Information Comment Organism
2.5.1.15 drug target target for anti-malarial and anti-bacterial drugs Yersinia pestis