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Literature summary extracted from

  • Zheng, Y.; Wang, J.; Zhou, S.; Zhang, Y.
    Liu, J.; Xue, C.-X.; Williams, B.T.; Zhao, X.; Zhao, L.; Zhu, X.-Y.; Sun, C.; Zhang, H.-H.; Xiao, T.; Yang, G.-P.; Todd, J.D.; Zhang, X.-H. Bacteria are important dimethylsulfoniopropionate producers in marine aphotic and high-pressure environments (2020), Nat. Commun., 11, 4658 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.373 S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate uncultured bacterium the enzyme is involved in biosynthesis of dimethylsulfoniopropionate S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.373 uncultured bacterium
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.373 S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate
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 uncultured bacterium S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate
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 ?
2.1.1.373 S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate the enzyme is involved in biosynthesis of dimethylsulfoniopropionate uncultured bacterium S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.373 dsyB
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 uncultured bacterium

General Information

EC Number General Information Comment Organism
2.1.1.373 malfunction metagenome data show that bacterial dsyB mutants are less tolerant of deep ocean pressures than wild-type strains uncultured bacterium
2.1.1.373 physiological function the enzyme is involved in biosynthesis of the marine osmolyte dimethylsulfoniopropionate (DMSP). The physiological function for DMSP in hydrostatic pressure protection. Bacteria are key DMSP producers in deep seawater and sediment. The genetic potential for bacterial DMSP synthesis via the dsyB gene and its transcription is greater in the deep ocean, and is highest in the sediment.s DMSP catabolic potential is present throughout the trench waters, but is less prominent below 8000 m, perhaps indicating a preference to store DMSP in the deep for stress protection. Deep ocean bacterial isolates show enhanced DMSP production under increased hydrostatic pressure. No eukaryotic DMSP synthesis genes are detected in any metagenomes, even from the surface waters uncultured bacterium