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Literature summary extracted from

  • Jansen, R.S.; Mandyoli, L.; Hughes, R.; Wakabayashi, S.; Pinkham, J.T.; Selbach, B.; Guinn, K.M.; Rubin, E.J.; Sacchettini, J.C.; Rhee, K.Y.
    Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis (2020), Nat. Commun., 11, 1960 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.1 2.34
-
 L-aspartate at pH 7.4 and 37°C Mycobacterium tuberculosis
2.6.1.1 29.4
-
 kynurenine at pH 7.4 and 37°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.1 L-aspartate + 2-oxoglutarate Mycobacterium tuberculosis
-
 oxaloacetate + L-glutamate
-
 ?
2.6.1.1 L-aspartate + 2-oxoglutarate Mycobacterium tuberculosis H37Rv
-
 oxaloacetate + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.1 Mycobacterium tuberculosis O69689
-
-
2.6.1.1 Mycobacterium tuberculosis H37Rv O69689
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.1 kynurenine + 2-oxoglutarate
-
 Mycobacterium tuberculosis ?
-
 ?
2.6.1.1 kynurenine + 2-oxoglutarate
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
2.6.1.1 L-aspartate + 2-oxoglutarate
-
 Mycobacterium tuberculosis oxaloacetate + L-glutamate
-
 ?
2.6.1.1 L-aspartate + 2-oxoglutarate
-
 Mycobacterium tuberculosis H37Rv oxaloacetate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.1 aspartate aminotransferase
-
 Mycobacterium tuberculosis
2.6.1.1 AspAT
-
 Mycobacterium tuberculosis
2.6.1.1 Rv3722c
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.1 136
-
 L-aspartate at pH 7.4 and 37°C Mycobacterium tuberculosis
2.6.1.1 198
-
 kynurenine at pH 7.4 and 37°C Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.1 pyridoxal 5'-phosphate
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.6.1.1 malfunction enzyme deficiency leads to virulence attenuation in macrophages and mice Mycobacterium tuberculosis
2.6.1.1 physiological function the enzyme is essential for virulence in macrophages and mice Mycobacterium tuberculosis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.6.1.1 6.73
-
 kynurenine at pH 7.4 and 37°C Mycobacterium tuberculosis
2.6.1.1 58.3
-
 L-aspartate at pH 7.4 and 37°C Mycobacterium tuberculosis