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Literature summary extracted from

  • Townsend, M.H.; Felsted, A.M.; Burrup, W.; Robison, R.A.; O'Neill, K.L.
    Examination of hypoxanthine guanine phosphoribosyltransferase as a biomarker for colorectal cancer patients (2018), Mol. Cell. Oncol., 5, e1481810 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.2.8 diagnostics there is other evidence of salvage enzymes serving as diagnostic and prognostic biomarkers to diagnose and monitor cancer development in patient. Evaluation of enzymes, including HPRT, APRT, and DCK, as potential biomarkers for colorectal cancer (CRC). Colorectal cancer cell lines SW-480, SW-620, and HT-29 have statistically significant HPRT expression on the surface of the cells, while Colo-205 cells show no significant increase in the surface presence of HPRT. Analysis within malignant colon samples confirms the variable nature of HPRT surface localization within patients Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.8 cell surface
-
 Homo sapiens 9986
-
2.4.2.8 additional information analysis within malignant colon samples confirms the variable nature of HPRT surface localization within patients Homo sapiens
-
-
2.4.2.8 plasma membrane HPRT is strongly associated with the plasma membrane of SW-620 cells Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.8 guanosine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 IMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.8 Homo sapiens P00492
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.8 Colo-205 cell
-
 Homo sapiens
-
2.4.2.8 colorectal cancer cell
-
 Homo sapiens
-
2.4.2.8 HT-29 cell
-
 Homo sapiens
-
2.4.2.8 SW-620 cell HPRT is strongly associated with the plasma membrane of SW-620 cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.8 guanosine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens IMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.8 HPRT
-
 Homo sapiens
2.4.2.8 hypoxanthine guanine phosphoribosyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.8 physiological function having functional salvage pathway enzymes is important in the survival and functionality of mammalian cells. Salvage enzymes, such as HPRT, are known as common housekeeping genes, and are integral in several daily cellular functions regulating cell proliferation and cell cycle progression Homo sapiens