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Literature summary extracted from

  • Pollard, D.J.; Berger, C.N.; So, E.C.; Yu, L.; Hadavizadeh, K.; Jennings, P.; Tate, E.W.; Choudhary, J.S.; Frankel, G.
    Broad-spectrum regulation of nonreceptor tyrosine kinases by the bacterial ADP-ribosyltransferase EspJ (2018), mBio, 9, e00170-18 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.30 D187A catalytically inactive Citrobacter rodentium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Btk Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Btk + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Csk Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Csk + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Hck Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Hck + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Lyn Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Lyn + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Src Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Src + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Syk Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Syk + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Tec Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Tec + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Yes1 Citrobacter rodentium
-
 nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Yes1 + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Citrobacter rodentium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Btk
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Btk + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Csk
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Csk + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Hck
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Hck + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Lyn
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Lyn + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Src
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Src + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Syk
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Syk + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Tec
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Tec + H+
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Yes1
-
 Citrobacter rodentium nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Yes1 + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.30 ? x * 60000, SDS-PAGE Citrobacter rodentium

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 ADP-ribosyltransferase
-
 Citrobacter rodentium
2.4.2.30 ART
-
 Citrobacter rodentium
2.4.2.30 EspJ
-
 Citrobacter rodentium

General Information

EC Number General Information Comment Organism
2.4.2.30 metabolism enzyme-induced ADP-ribosylation regulates multiple nonreceptor tyrosine kinases in vivo Citrobacter rodentium
2.4.2.30 physiological function the enzyme regulates the host immune response in vivo by targeting its kinases Citrobacter rodentium