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Literature summary extracted from

  • Zhao, Z.; Bourne, P.E.
    Structural insights into the binding modes of viral RNA-dependent RNA polymerases using a function-site interaction fingerprint method for RNA virus drug discovery (2020), J. Proteome Res., 19, 4698-4705 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2
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 diphosphate + RNAn+1
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDRP
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 Severe acute respiratory syndrome coronavirus 2
2.7.7.48 RNA-dependent RNA polymerase
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 Severe acute respiratory syndrome coronavirus 2

General Information

EC Number General Information Comment Organism
2.7.7.48 drug target the structural characteristics of the catalytic domain of the RNA-dependent RNA polymerase are explored using a computational pharmacology method. Ligand-binding characteristics of the binding site are determined using a receptor-ligand function-site interaction fingerprint strategy. Binding characteristics determined by this method help to rationalize RNA-dependent RNA polymerase-targeted drug discovery and provide insights into the specific binding mechanisms important for containing the SARS-CoV-2 virus Severe acute respiratory syndrome coronavirus 2