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Literature summary extracted from

  • Kandepedu, N.; Gonzalez Cabrera, D.; Eedubilli, S.; Taylor, D.; Brunschwig, C.; Gibhard, L.; Njoroge, M.; Lawrence, N.; Paquet, T.; Eyermann, C.J.; Spangenberg, T.; Basarab, G.S.; Street, L.J.; Chibale, K.
    Identification, characterization, and optimization of 2,8-disubstituted-1,5-naphthyridines as novel Plasmodium falciparum phosphatidylinositol-4-kinase inhibitors with in vivo efficacy in a humanized mouse model of malaria (2018), J. Med. Chem., 61, 5692-5703 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 (1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide BRD73842 Plasmodium falciparum
2.7.1.67 (1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide BRD73842 Plasmodium vivax
2.7.1.67 (3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
-
 Plasmodium falciparum
2.7.1.67 (3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
-
 Plasmodium vivax
2.7.1.67 1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
-
 Plasmodium falciparum
2.7.1.67 1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
-
 Plasmodium vivax
2.7.1.67 2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
-
 Plasmodium falciparum
2.7.1.67 2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
-
 Plasmodium vivax
2.7.1.67 2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
2.7.1.67 2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
2.7.1.67 2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide BQR695 Plasmodium falciparum
2.7.1.67 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide BQR695 Plasmodium vivax
2.7.1.67 3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
-
 Plasmodium falciparum
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
-
 Plasmodium vivax
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
2.7.1.67 4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
2.7.1.67 4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine MMV390048 Plasmodium falciparum
2.7.1.67 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine MMV390048 Plasmodium vivax
2.7.1.67 5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide MMV024101 Plasmodium falciparum
2.7.1.67 5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide MMV024101 Plasmodium vivax
2.7.1.67 5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium vivax
2.7.1.67 5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium vivax
2.7.1.67 5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
-
 Plasmodium vivax
2.7.1.67 8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
-
 Plasmodium falciparum
2.7.1.67 8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
-
 Plasmodium vivax
2.7.1.67 artesunate
-
 Plasmodium falciparum
2.7.1.67 artesunate
-
 Plasmodium vivax
2.7.1.67 BQR695
-
 Plasmodium falciparum
2.7.1.67 BQR695
-
 Plasmodium vivax
2.7.1.67 BRD73842
-
 Plasmodium falciparum
2.7.1.67 BRD73842
-
 Plasmodium vivax
2.7.1.67 Chloroquine
-
 Plasmodium falciparum
2.7.1.67 Chloroquine
-
 Plasmodium vivax
2.7.1.67 KDU691
-
 Plasmodium falciparum
2.7.1.67 KDU691
-
 Plasmodium vivax
2.7.1.67 MMV390048
-
 Plasmodium falciparum
2.7.1.67 MMV390048
-
 Plasmodium vivax
2.7.1.67 N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium falciparum
2.7.1.67 N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium vivax
2.7.1.67 N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide KDU691 Plasmodium falciparum
2.7.1.67 N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide KDU691 Plasmodium vivax
2.7.1.67 N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium falciparum
2.7.1.67 N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium vivax
2.7.1.67 N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
-
 Plasmodium vivax
2.7.1.67 N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
2.7.1.67 N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
2.7.1.67 N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium falciparum
2.7.1.67 N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
-
 Plasmodium vivax
2.7.1.67 N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
-
 Plasmodium vivax
2.7.1.67 N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium falciparum
2.7.1.67 N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
-
 Plasmodium vivax
2.7.1.67 N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
-
 Plasmodium vivax
2.7.1.67 N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
-
 Plasmodium falciparum
2.7.1.67 N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
-
 Plasmodium vivax

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Plasmodium falciparum
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Plasmodium vivax
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Plasmodium falciparum
-
 chloroquine sensitive (NF54) strain
-
2.7.1.67 Plasmodium falciparum
-
 multidrug resistant (K1) strain
-
2.7.1.67 Plasmodium vivax
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Plasmodium falciparum ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Plasmodium vivax ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 phosphatidylinositol-4-kinase
-
 Plasmodium falciparum
2.7.1.67 phosphatidylinositol-4-kinase
-
 Plasmodium vivax
2.7.1.67 PI4K
-
 Plasmodium falciparum
2.7.1.67 PI4K
-
 Plasmodium vivax

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.67 0.0000015
-
 pH and temperature not specified in the publication Plasmodium vivax N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
2.7.1.67 0.0000015
-
 pH and temperature not specified in the publication Plasmodium vivax KDU691
2.7.1.67 0.0000034
-
 pH and temperature not specified in the publication Plasmodium vivax 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine
2.7.1.67 0.0000034
-
 pH and temperature not specified in the publication Plasmodium vivax MMV390048
2.7.1.67 0.0000035
-
 pH and temperature not specified in the publication Plasmodium vivax 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
2.7.1.67 0.0000035
-
 pH and temperature not specified in the publication Plasmodium vivax BQR695
2.7.1.67 0.000019
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.00002
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000021
-
 pH and temperature not specified in the publication Plasmodium vivax (1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide
2.7.1.67 0.000021
-
 pH and temperature not specified in the publication Plasmodium vivax BRD73842
2.7.1.67 0.000022
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000025
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
2.7.1.67 0.000029
-
 pH and temperature not specified in the publication Plasmodium falciparum 1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
2.7.1.67 0.000031
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
2.7.1.67 0.000031
-
 pH and temperature not specified in the publication Plasmodium falciparum N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000046
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
2.7.1.67 0.000046
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.00005
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000063
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000065
-
 pH and temperature not specified in the publication Plasmodium falciparum N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000084
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
2.7.1.67 0.000084
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000087
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
2.7.1.67 0.000091
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000102
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000105
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.00011
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
2.7.1.67 0.000119
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000122
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000147
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
2.7.1.67 0.000187
-
 pH and temperature not specified in the publication Plasmodium falciparum (3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
2.7.1.67 0.000203
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000215
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000238
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000265
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000277
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000284
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
2.7.1.67 0.000355
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
2.7.1.67 0.000377
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
2.7.1.67 0.000412
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000424
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
2.7.1.67 0.000437
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000457
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000496
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
2.7.1.67 0.000543
-
 pH and temperature not specified in the publication Plasmodium falciparum 5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
2.7.1.67 0.000708
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000719
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
2.7.1.67 0.000727
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.000728
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
2.7.1.67 0.000745
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
2.7.1.67 0.00091
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
2.7.1.67 0.000935
-
 pH and temperature not specified in the publication Plasmodium falciparum 3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
2.7.1.67 0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum 2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
2.7.1.67 0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum 8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
2.7.1.67 0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
2.7.1.67 0.001
-
 IC50 above 0.001 mM, pH and temperature not specified in the publication Plasmodium falciparum N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
2.7.1.67 0.001015
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.00136
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
2.7.1.67 0.001432
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
2.7.1.67 0.001484
-
 pH and temperature not specified in the publication Plasmodium falciparum 8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
2.7.1.67 0.001755
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
2.7.1.67 0.002623
-
 pH and temperature not specified in the publication Plasmodium falciparum N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
2.7.1.67 0.003668
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
2.7.1.67 0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum 2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum 4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
2.7.1.67 0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum 4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
2.7.1.67 0.005
-
 IC50 above 0.005 mM, pH and temperature not specified in the publication Plasmodium falciparum N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
2.7.1.67 0.00618
-
 pH and temperature not specified in the publication Plasmodium falciparum N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide