EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.12 | (2E)-3-(6-aminopyridin-3-yl)-N-((5-[4-(4,4-difluoropiperidine-1-carbonyl)phenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl)methyl)prop-2-enamide | KPT-9274 | Mus musculus | |
2.4.2.12 | (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)prop-2-enamide | FK866, potent inhibitor | Mus musculus | |
2.4.2.12 | 1-([1,1'-biphenyl]-2-yl)-3-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)urea | - |
Mus musculus | |
2.4.2.12 | 3-(1-(4-(2-([1,1'-biphenyl]-2-yloxy)ethyl)benzyl)-1H-1,2,3-triazol-4-yl)pyridine | - |
Mus musculus | |
2.4.2.12 | 3-(1-(6-([1,1'-biphenyl]-2-yloxy)hexyl)-1H-1,2,3-triazol-4-yl)-pyridine | - |
Mus musculus | |
2.4.2.12 | 3-(1-(7-(4-([1,1'-biphenyl]-2-yl)-1H-1,2,3-triazol-1-yl)-heptyl)-1H-1,2,3-triazol-4-yl)pyridine | - |
Mus musculus | |
2.4.2.12 | 3-(1-(7-([1,1'-biphenyl]-2-yloxy)heptyl)-1H-1,2,3-triazol-4-yl)pyridine | - |
Mus musculus | |
2.4.2.12 | 3-(1-(8-([1,1'-biphenyl]-2-yloxy)octyl)-1H-1,2,3-triazol-4-yl)-pyridine | - |
Mus musculus | |
2.4.2.12 | N-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)-[1,1'-biphenyl]-2-carboxamide | - |
Mus musculus | |
2.4.2.12 | N-(8-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)octyl)biphenyl-2-sulfonamide | - |
Mus musculus | |
2.4.2.12 | N-([1,1'-biphenyl]-2-yl)-8-(2-(pyridin-3-yl)thiazol-5-yl)-octanamide | - |
Mus musculus | |
2.4.2.12 | N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)octanamide | - |
Mus musculus | |
2.4.2.12 | N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-1H-pyrazol-3-yl)-octanamide | - |
Mus musculus | |
2.4.2.12 | N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)octanamide | - |
Mus musculus | |
2.4.2.12 | N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)isoxazol-3-yl)-octanamide | - |
Mus musculus | |
2.4.2.12 | N-([1,1'-biphenyl]-2-yl)-8-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]octanamide | GPP78 | Mus musculus | |
2.4.2.12 | N-[6-(4-chlorophenoxy)hexyl]-N''-cyano-N'-phenylguanidine | CHS828, potent inhibitor | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.12 | nicotinamide D-ribonucleotide + diphosphate | Mus musculus | - |
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.12 | Mus musculus | Q99KQ4 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.12 | nicotinamide D-ribonucleotide + diphosphate | - |
Mus musculus | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.2.12 | Nampt | - |
Mus musculus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.4.2.12 | 0.0000031 | - |
at pH 7.5 and 37°C | Mus musculus | N-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)-[1,1'-biphenyl]-2-carboxamide | |
2.4.2.12 | 0.0000038 | - |
at pH 7.5 and 37°C | Mus musculus | 3-(1-(6-([1,1'-biphenyl]-2-yloxy)hexyl)-1H-1,2,3-triazol-4-yl)-pyridine | |
2.4.2.12 | 0.0000049 | - |
at pH 7.5 and 37°C | Mus musculus | (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)prop-2-enamide | |
2.4.2.12 | 0.0000081 | - |
at pH 7.5 and 37°C | Mus musculus | 3-(1-(7-(4-([1,1'-biphenyl]-2-yl)-1H-1,2,3-triazol-1-yl)-heptyl)-1H-1,2,3-triazol-4-yl)pyridine | |
2.4.2.12 | 0.0000102 | - |
at pH 7.5 and 37°C | Mus musculus | N-([1,1'-biphenyl]-2-yl)-8-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]octanamide | |
2.4.2.12 | 0.0000156 | - |
at pH 7.5 and 37°C | Mus musculus | 3-(1-(4-(2-([1,1'-biphenyl]-2-yloxy)ethyl)benzyl)-1H-1,2,3-triazol-4-yl)pyridine | |
2.4.2.12 | 0.0000254 | - |
at pH 7.5 and 37°C | Mus musculus | 3-(1-(8-([1,1'-biphenyl]-2-yloxy)octyl)-1H-1,2,3-triazol-4-yl)-pyridine | |
2.4.2.12 | 0.0000313 | - |
at pH 7.5 and 37°C | Mus musculus | 3-(1-(7-([1,1'-biphenyl]-2-yloxy)heptyl)-1H-1,2,3-triazol-4-yl)pyridine | |
2.4.2.12 | 0.0000324 | - |
at pH 7.5 and 37°C | Mus musculus | 1-([1,1'-biphenyl]-2-yl)-3-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)urea | |
2.4.2.12 | 0.000047 | - |
at pH 7.5 and 37°C | Mus musculus | N-(8-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)octyl)biphenyl-2-sulfonamide | |
2.4.2.12 | 0.0000499 | - |
at pH 7.5 and 37°C | Mus musculus | N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)isoxazol-3-yl)-octanamide | |
2.4.2.12 | 0.000269 | - |
at pH 7.5 and 37°C | Mus musculus | N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)octanamide |