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Literature summary extracted from

  • Sengupta, N.; Jovic, M.; Barnaeva, E.; Kim, D.W.; Hu, X.; Southall, N.; Dejmek, M.; Mejdrova, I.; Nencka, R.; Baumlova, A.; Chalupska, D.; Boura, E.; Ferrer, M.; Marugan, J.; Balla, T.
    A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha (2019), J. Lipid Res., 60, 683-693 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 2-[[(2-methoxyphenyl)methyl]amino]-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate
-
 Homo sapiens
2.7.1.67 4-[4-[(2-oxo-2,3-dihydro-1H-indol-5-yl)sulfonyl]piperazin-1-yl]benzaldehyde
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.67 expressed in Escherichia coli BL21 NiCo cells and COS-7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 (2-bromo-4,5-dimethoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanone about 80% residual activity at 0.01 mM Homo sapiens
2.7.1.67 1,10-phenanthroline-5,6-dione about 35% residual activity at 0.01 mM Homo sapiens
2.7.1.67 1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione about 65% residual activity at 0.01 mM Homo sapiens
2.7.1.67 2-[5-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-3-yl]pyridine about 18% residual activity at 0.01 mM Homo sapiens
2.7.1.67 3-(4-methylphenyl)-5H-indeno[1,2-c]pyridazin-5-one about 55% residual activity at 0.01 mM Homo sapiens
2.7.1.67 4-(quinoxalin-2-yl)phenyl furan-2-carboxylate about 75% residual activity at 0.01 mM Homo sapiens
2.7.1.67 methyl N-[[(4-butyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetyl]-5-hydroxy-L-tryptophanate
-
 Homo sapiens
2.7.1.67 N'-(4-methoxybenzoyl)pyridine-2-carbohydrazide about 20% residual activity at 0.01 mM Homo sapiens
2.7.1.67 N'-[(4-methoxybenzoyl)oxy]pyridine-2-carboximidamide about 30% residual activity at 0.01 mM Homo sapiens
2.7.1.67 N-(1H-benzimidazol-2-yl)-2-methoxybenzamide about 65% residual activity at 0.01 mM Homo sapiens
2.7.1.67 N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide about 40% residual activity at 0.01 mM Homo sapiens
2.7.1.67 N-[5-[4-(dimethylamino)phenyl]-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]pyridine-2-carboxamide about 95% residual activity at 0.01 mM Homo sapiens
2.7.1.67 N-[[(4-butyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetyl]-5-hydroxy-L-tryptophan about 20% residual activity at 0.01 mM Homo sapiens
2.7.1.67 propan-2-yl N-[[(4-butyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetyl]-5-hydroxy-L-tryptophanate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 endosome
-
 Homo sapiens 5768
-
2.7.1.67 Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.67 Ni-NTA agarose column chromatography and Mono-Q column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 HEK-293-AT1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 phosphatidylinositol 4-kinase type II alpha
-
 Homo sapiens
2.7.1.67 PI4K2A
-
 Homo sapiens