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Literature summary extracted from

  • Kaburagi, T.; Kizuka, Y.; Kitazume, S.; Taniguchi, N.
    The inhibitory Role of alpha2,6-sialylation in adipogenesis (2017), J. Biol. Chem., 292, 2278-2286 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Mus musculus Q64685
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 3T3-L1 cell
-
 Mus musculus
-
2.4.3.1 abdominal adipose tissue
-
 Mus musculus
-
2.4.3.1 adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetyl-beta-neuraminate + integrin-beta1
-
 Mus musculus CMP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 beta-galactoside alpha2,6-sialyltransferase-1
-
 Mus musculus
2.4.3.1 ST6Gal1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.3.1 metabolism the enzyme is responsible for the biosynthesis of alpha2,6-linked sialic acid in N-linked glycans Mus musculus
2.4.3.1 physiological function enzyme overexpression in differentiating 3T3-L1 cells inhibits adipogenesis with increased phosphorylation of focal adhesion kinase. The enzyme has an inhibitory role in adipogenesis through integrin-beta1 activation Mus musculus