Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Inokoshi, J.; Nakamura, Y.; Komada, S.; Komatsu, K.; Umeyama, H.; Tomoda, H.
    Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules (2016), J. Antibiot., 69, 798-805 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.90 expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.90 spirohexaline
-
 Escherichia coli
2.5.1.90 viridicatumtoxin
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.90 Mg2+ 0.5 mM used in assay conditions Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.90 (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate Escherichia coli
-
 5 diphosphate + all-trans-octaprenyl diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.90 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.90
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.90 (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate
-
 Escherichia coli 5 diphosphate + all-trans-octaprenyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.90 octaprenyl pyrophosphate synthase
-
 Escherichia coli
2.5.1.90 OPP synthase
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.90 0.0164
-
 at pH 7.5 and 37°C Escherichia coli viridicatumtoxin
2.5.1.90 0.0646
-
 at pH 7.5 and 37°C Escherichia coli spirohexaline