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Literature summary extracted from
- Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin Involvement of an unprecedented N-oxygenase (2004), J. Am. Chem. Soc., 126, 3694-3695 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.99.68 | expression in Streptomyces lividans | Streptomyces thioluteus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.68 | 4-aminobenzoate + reduced acceptor + 2 O2 | Streptomyces thioluteus | - |
4-nitrobenzoate + acceptor + 2 H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.68 | Streptomyces thioluteus | Q70KH9 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.68 | 4-aminobenzoate + reduced acceptor + 2 O2 | - |
Streptomyces thioluteus | 4-nitrobenzoate + acceptor + 2 H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.68 | aurF | - |
Streptomyces thioluteus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.99.68 | physiological function | in-frame deletion of aurF yields a mutant, in which both N-oxidation activity and aureothin production is abolished. Aureothin biosynthesis in the mutant can be fully restored upon supplying the culture with synthetic 4-nitrobenzoate | Streptomyces thioluteus |
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Release 2023.1 (January 2023)
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