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Literature summary extracted from

  • Yu, Y.; Yang, J.; Zheng, L.; Sheng, Q.; Li, C.; Wang, M.; Zhang, X.; McMinn, A.; Zhang, Y.; Song, X.; Chen, X.
    Diversity of D-amino acid utilizing bacteria from Kongsfjorden, Arctic, and the metabolic pathways for seven D-amino acids (2020), Front. Microbiol., 10, 2983 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.21 gene FQP89_01185, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, quantitative RT-PCR enzyme expression analysis, recombinant expression in Escherichia coli strain BL21(DE3) Halomonas titanicae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.21 D-alanine + 2-oxoglutarate Halomonas titanicae
-
 pyruvate + D-glutamate
-
 r
2.6.1.21 D-alanine + 2-oxoglutarate Halomonas titanicae SM1922
-
 pyruvate + D-glutamate
-
 r
2.6.1.21 D-aspartate + 2-oxoglutarate Halomonas titanicae
-
 2-oxosuccinate + D-glutamate
-
 r
2.6.1.21 D-aspartate + 2-oxoglutarate Halomonas titanicae SM1922
-
 2-oxosuccinate + D-glutamate
-
 r
2.6.1.21 D-leucine + 2-oxoglutarate Halomonas titanicae
-
 4-methyl-2-oxopentanoate + D-glutamate
-
 r
2.6.1.21 D-methionine + 2-oxoglutarate Halomonas titanicae
-
 4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-methionine + 2-oxoglutarate Halomonas titanicae SM1922
-
 4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-phenylalanine + 2-oxoglutarate Halomonas titanicae
-
 phenylpyruvate + D-glutamate
-
 r
2.6.1.21 D-serine + 2-oxoglutarate Halomonas titanicae
-
 3-hydroxy-2-oxopropanoate + D-glutamate
-
 r
2.6.1.21 D-threonine + 2-oxoglutarate Halomonas titanicae
-
 2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-tyrosine + 2-oxoglutarate Halomonas titanicae
-
 3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate
-
 r
2.6.1.21 additional information Halomonas titanicae in vivo substrate specificity of strain SM1922 ?
-
-
2.6.1.21 additional information Halomonas titanicae SM1922 in vivo substrate specificity of strain SM1922 ?
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.21 Halomonas titanicae A0A558JDR6
-
-
2.6.1.21 Halomonas titanicae SM1922 A0A558JDR6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.21 additional information relative transcriptional levels of gene FQP89_15030 (FAD-binding oxidoreductase), FQP89_01690 (DAA dehydrogenase 3 small subunit), FQP89_11185 (FAD-binding oxidoreductase) and FQP89_01185 (D-amino-acid transaminase) in strain SM1922 cultured with D-Asp (A), D-Leu (B), and D-Thr (C) as a sole nitrogen source, respectively, overview. Quantitative RT-PCR genes expression analysis Halomonas titanicae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.21 D-alanine + 2-oxoglutarate
-
 Halomonas titanicae pyruvate + D-glutamate
-
 r
2.6.1.21 D-alanine + 2-oxoglutarate
-
 Halomonas titanicae SM1922 pyruvate + D-glutamate
-
 r
2.6.1.21 D-aspartate + 2-oxoglutarate
-
 Halomonas titanicae 2-oxosuccinate + D-glutamate
-
 r
2.6.1.21 D-aspartate + 2-oxoglutarate
-
 Halomonas titanicae SM1922 2-oxosuccinate + D-glutamate
-
 r
2.6.1.21 D-leucine + 2-oxoglutarate
-
 Halomonas titanicae 4-methyl-2-oxopentanoate + D-glutamate
-
 r
2.6.1.21 D-leucine + 2-oxoglutarate high activity Halomonas titanicae 4-methyl-2-oxopentanoate + D-glutamate
-
 r
2.6.1.21 D-methionine + 2-oxoglutarate
-
 Halomonas titanicae 4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-methionine + 2-oxoglutarate low activity Halomonas titanicae 4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-methionine + 2-oxoglutarate
-
 Halomonas titanicae SM1922 4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-methionine + 2-oxoglutarate low activity Halomonas titanicae SM1922 4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-phenylalanine + 2-oxoglutarate
-
 Halomonas titanicae phenylpyruvate + D-glutamate
-
 r
2.6.1.21 D-serine + 2-oxoglutarate
-
 Halomonas titanicae 3-hydroxy-2-oxopropanoate + D-glutamate
-
 r
2.6.1.21 D-serine + 2-oxoglutarate best substrate Halomonas titanicae 3-hydroxy-2-oxopropanoate + D-glutamate
-
 r
2.6.1.21 D-threonine + 2-oxoglutarate
-
 Halomonas titanicae 2-oxobutanoate + D-glutamate
-
 r
2.6.1.21 D-tyrosine + 2-oxoglutarate
-
 Halomonas titanicae 3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate
-
 r
2.6.1.21 D-tyrosine + 2-oxoglutarate low activity Halomonas titanicae 3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate
-
 r
2.6.1.21 additional information in vivo substrate specificity of strain SM1922 Halomonas titanicae ?
-
-
2.6.1.21 additional information in vivo substrate specificity of strain SM1922 Halomonas titanicae SM1922 ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.6.1.21 D-alanine:2-oxoglutarate aminotransferase UniProt Halomonas titanicae
2.6.1.21 DAA aminotransferase
-
 Halomonas titanicae
2.6.1.21 DAA transaminase
-
 Halomonas titanicae
2.6.1.21 FQP89_01185 locus name Halomonas titanicae
2.6.1.21 TRA-01185
-
 Halomonas titanicae

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.21 pyridoxal 5'-phosphate PLP Halomonas titanicae

General Information

EC Number General Information Comment Organism
2.6.1.21 evolution diversity of D-amino acid utilizing bacteria from Kongsfjorden, Arctic, and the metabolic pathways for seven D-amino acids, analysis of key genes predicted to be involved in D-amino acid catabolism in the bacterial strains, detailed overview Halomonas titanicae
2.6.1.21 metabolism the enzyme is involved int he D-Ala and D-Asp metabolism in strain SM1922 of the arctic ocean bacterium. Pathways for D-Leu, D-Met, D-Phe, D-Thr, D-Tyr, D-Ser, and D-Asp metabolism in the isolated marine bacteria, overview Halomonas titanicae